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Titolo:
Immediate reorganization of the rat somatosensory thalamus after partial ligation of sciatic nerve
Autore:
Bruggemann, J; Galhardo, V; Apkarian, AV;
Indirizzi:
SUNY Syracuse, Hlth Sci Ctr, Dept Neurosurg, Syracuse, NY 13210 USA SUNY Syracuse Syracuse NY USA 13210 ept Neurosurg, Syracuse, NY 13210 USA Univ Oporto, IBMC, P-4204 Oporto, Portugal Univ Oporto Oporto Portugal P-4204 Oporto, IBMC, P-4204 Oporto, Portugal Univ Oporto, Fac Med, Inst Histol & Embryol, P-4204 Oporto, Portugal Univ Oporto Oporto Portugal P-4204 ol & Embryol, P-4204 Oporto, Portugal
Titolo Testata:
JOURNAL OF PAIN
fascicolo: 4, volume: 2, anno: 2001,
pagine: 220 - 228
SICI:
1526-5900(200108)2:4<220:IROTRS>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXPERIMENTAL PERIPHERAL NEUROPATHY; SPINAL-CORD; STIMULATION; NEURONS; PAIN; MONONEUROPATHY; NUCLEUS; DEAFFERENTATION; DISORDERS; SENSATION;
Keywords:
somatosensory thalamus; pain; neuropathic; reorganization; ligation; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Apkarian, AV Northwestern Univ, Sch Med, Dept Physiol, Tarry Bldg,5-703,330 E Superior St, Chicago, IL 60611 USA Northwestern Univ Tarry Bldg,5-703,330 E Superior St Chicago IL USA 60611
Citazione:
J. Bruggemann et al., "Immediate reorganization of the rat somatosensory thalamus after partial ligation of sciatic nerve", J PAIN, 2(4), 2001, pp. 220-228

Abstract

Nerve injury can result in neuropathic pain, which persists after the injury and may occur after healing is completed. The long-term central reorganization associated with neuropathic pain has been previously studied in animal models. The immediate effects of nerve injury on central representation,however, are poorly understood. We examined the population response properties of closely neighboring neurons located in the hindlimb representation area of the somatosensory thalamus. Changes in the neuronal population properties were characterized before, during, and after (up to 6 hours) partialligation of the sciatic nerve in the rat. Changes in these properties wereobserved within minutes after nerve injury. There were changes in neuronalclass and receptive field size, emergence of new receptive fields, receptive fields observed before ligation disappeared temporarily after ligation, and changes in number of spikes evoked by the same stimulus. The rates of these changes in central representation were essentially zero before ligation, maximal within minutes after ligation, and decreased to a steady sustained rate of change within 1 to 2 hours. The incidence of functional connectivity, as measured by cross-correlations, remained unchanged. However, the strength of functional connectivity increased after ligation. The results show immediate reorganization of lateral thalamic networks with peripheral nerve damage. When the population response is considered as the underlying code, this reorganization does not reflect the behavioral manifestations of hyperalgesia and allodynia, even though some of the individual neuronal responses do reflect properties consistent with the hyperalgesia and allodynia reported within the same time frame after nerve injury in the rat. (C) 2001by the American Pain Society.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 14:19:36