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Titolo:
Neuropsychiatric aspects of Huntington's disease
Autore:
Paulsen, JS; Ready, RE; Hamilton, JM; Mega, MS; Cummings, JL;
Indirizzi:
Univ Iowa, Dept Psychiat, Iowa City, IA 52242 USA Univ Iowa Iowa City IA USA 52242 , Dept Psychiat, Iowa City, IA 52242 USA Univ Iowa, Dept Neurol, Iowa City, IA 52242 USA Univ Iowa Iowa City IA USA 52242 wa, Dept Neurol, Iowa City, IA 52242 USA UCSD, Sch Med, Dept Psychiat, San Diego, CA USA UCSD San Diego CA USAUCSD, Sch Med, Dept Psychiat, San Diego, CA USA SDSU, Dept Psychol, San Diego, CA USA SDSU San Diego CA USASDSU, Dept Psychol, San Diego, CA USA UCLA, Sch Med, Dept Neurol, Los Angeles, CA USA UCLA Los Angeles CA USAUCLA, Sch Med, Dept Neurol, Los Angeles, CA USA UCLA, Sch Med, Dept Psychiat, Los Angeles, CA USA UCLA Los Angeles CA USA CLA, Sch Med, Dept Psychiat, Los Angeles, CA USA UCLA, Sch Med, Dept Biobehav Sci, Los Angeles, CA USA UCLA Los Angeles CAUSA Sch Med, Dept Biobehav Sci, Los Angeles, CA USA Univ Iowa, Dept Psychol, Iowa City, IA 52242 USA Univ Iowa Iowa City IA USA 52242 a, Dept Psychol, Iowa City, IA 52242 USA
Titolo Testata:
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
fascicolo: 3, volume: 71, anno: 2001,
pagine: 310 - 314
SICI:
0022-3050(200109)71:3<310:NAOHD>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
PSYCHOPATHOLOGY; DISORDERS; CIRCUITS; DEMENTIA;
Keywords:
Huntington's disease; neuropsychiatry; dementia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Paulsen, JS Univ Iowa, Dept Psychiat, 288 JPP,200 Hawkins Dr, Iowa City, IA 52242 USA Univ Iowa 288 JPP,200 Hawkins Dr Iowa City IA USA 52242 42 USA
Citazione:
J.S. Paulsen et al., "Neuropsychiatric aspects of Huntington's disease", J NE NE PSY, 71(3), 2001, pp. 310-314

Abstract

Objective-Neuropsychiatric symptoms are common in Huntington's disease andhave been considered its presenting manifestation. Research characterisingthese symptoms in Huntington's disease is variable, however, encumbered bylimitations within and across studies. Gaining a better understanding of neuropsychiatric symptoms is essential, as these symptoms have implications for disease management, prognosis, and quality of life for patients and caregivers. Method-Fifty two patients with Huntington's disease were administered standardised measures of cognition, psychiatric symptoms, and motor abnormalities. Patient caregivers were administered the neuropsychiatric inventory. Results-Ninety eight per cent of the patients exhibited neuropsychiatric symptoms, the most prevalent being dysphoria, agitation, irritability, apathy, and anxiety. Symptoms ranged from mild to severe and were unrelated to dementia and chorea. Conclusions-Neuropsychiatric symptoms are prevalent in Huntington's disease and are relatively independent of cognitive and motor aspects of the disease. Hypothesised links between neuropsychiatric symptoms of Huntington's disease and frontal-striatal circuitry were explored. Findings indicate thatdimensional measures of neuropsychiatric symptoms are essential to capturethe full range of pathology in Huntington's disease and are vital to include in a comprehensive assessment of the disease.

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Documento generato il 14/07/20 alle ore 03:52:20