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Titolo:
CD44-mediated oncogenic signaling and cytoskeleton activation during mammary tumor progression
Autore:
Bourguignon, LYW;
Indirizzi:
Univ Miami, Sch Med, Dept Cell Biol & Anat, Miami, FL 33136 USA Univ Miami Miami FL USA 33136 Dept Cell Biol & Anat, Miami, FL 33136 USA
Titolo Testata:
JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA
fascicolo: 3, volume: 6, anno: 2001,
pagine: 287 - 297
SICI:
1083-3021(200107)6:3<287:COSACA>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
LYMPHOCYTE HOMING RECEPTOR; HUMAN BREAST-CANCER; ENDOTHELIAL-CELL PROLIFERATION; HUMAN ERYTHROCYTE ANKYRIN; KINASE RHO-KINASE; GROWTH-FACTOR; CD44 ISOFORMS; TRANSMEMBRANE GLYCOPROTEIN; EXTRACELLULAR-MATRIX; HYALURONATE RECEPTOR;
Keywords:
CD44; oncogenic signaling; ankyrin; Rho GTPases; breast tumor progression;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
67
Recensione:
Indirizzi per estratti:
Indirizzo: Bourguignon, LYW Univ Calif San Francisco, VA Med Ctr, Dept Med, San Francisco, CA 94121 USA Univ Calif San Francisco San Francisco CA USA 94121 USA
Citazione:
L.Y.W. Bourguignon, "CD44-mediated oncogenic signaling and cytoskeleton activation during mammary tumor progression", J MAMMARY G, 6(3), 2001, pp. 287-297

Abstract

CD44, a hyaluronan (HA)(3) receptor, belongs to a family of transmembrane glycoproteins which exists as several isoforms. Cell surface expression of certain CD44 isoforms is closely correlated with the progression and prognosis of breast cancers. A number of angiogenic factors (e.g., VEGF and FGF-2) and matrix degrading enzymes (MMPs) are tightly complexed with CD44 isoforms, suggesting that they are involved in the onset of oncogenic signals required for breast tumor cell invasion and migration. Most importantly, interaction of extracellular matrix components (e.g., HA) with cells triggers the cytoplasmic domain of CD44 isoforms to bind its unique downstream effectors (e.g., the cytoskeletal protein ankyrin or various oncogenic signaling molecules-Tiam1, RhoA-activated ROK, c-Src kinase and p185(HER2)) and to coordinate intracellular signaling pathways (e.g., Rho/Ras signaling and receptor-linked/non-receptor-linked tyrosine kinase pathways), leading to a concomitant onset of multiple cellular functions (e.g., tumor cell growth, migration and invasion) and breast tumor progression.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 16:44:05