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Titolo:
Bursting properties of caudal neurosecretory cells in the flounder Platichthys flesus, in vitro
Autore:
Brierley, MJ; Ashworth, AJ; Banks, JR; Balment, RJ; McCrohan, CR;
Indirizzi:
Univ Manchester, Sch Biol Sci, Manchester, Lancs, England Univ ManchesterManchester Lancs England Sci, Manchester, Lancs, England
Titolo Testata:
JOURNAL OF EXPERIMENTAL BIOLOGY
fascicolo: 15, volume: 204, anno: 2001,
pagine: 2733 - 2739
SICI:
0022-0949(200108)204:15<2733:BPOCNC>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
UROTENSIN-II; RECEPTOR ACTIVATION; ELECTRICAL-ACTIVITY; NEURONS; SYSTEM; VASOPRESSIN; OXYTOCIN; TELEOST; SEROTONIN; PITUITARY;
Keywords:
neurosecretion; bursting; electrophysiology; flounder; Platichthys flesus; osmoregulation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: McCrohan, CR Univ Manchester, Sch Biol Sci, Manchester, Lancs, England Univ Manchester Manchester Lancs England er, Lancs, England
Citazione:
M.J. Brierley et al., "Bursting properties of caudal neurosecretory cells in the flounder Platichthys flesus, in vitro", J EXP BIOL, 204(15), 2001, pp. 2733-2739

Abstract

Bursting activity in type 1 Dahlgren cells was studied using intra- and extracellular recording from an in vitro preparation of the caudal neurosecretory system of the euryhaline flounder. 45 % of cells showed spontaneous bursts of approximately 120s duration and 380s cycle period. Similar bursts were triggered by short duration (<5 s) depolarising or hyperpolarising pulses. Cells displayed a characteristic depolarising after potential, following either an action potential with associated afterhyperpolarisation, or a hyperpolarising current pulse. This depolarising after potential was relatedto a 'sag' potential, which developed during the hyperpolarising pulse. Both the depolarising after potential and the sag potential occurred only in cells at more depolarised (<60 mV) holding potentials. In addition, the amplitude of the depolarising after potential was dependent on the amplitude and the duration of the hyperpolarising pulse. The depolarising after potential following action potentials may provide a mechanism for facilitating repetitive firing during a burst. Extracellular recording revealed similar bursting in individual units which was not, however, synchronised between units. Spontaneous bursting activity recorded both intra- and extracellularly was inhibited by application of a known neuromodulator of the system, 5-hydroxytryptamine. This study provides a basis for investigating the relationship between physiological status, Dahlgren cell activity and neuropeptide secretion.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 04:27:15