Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Effects of Ferula gummosa Boiss. fractions on morphine dependence in mice
Autore:
Ramezani, M; Hosseinzadeh, H; Mojtahedi, K;
Indirizzi:
Mashhad Univ Med Sci, Sch Pharm, Dept Pharmacognosy & Biotechnol, Mashhad,Iran Mashhad Univ Med Sci Mashhad Iran rmacognosy & Biotechnol, Mashhad,Iran Mashhad Univ Med Sci, Sch Pharm, Dept Pharmacodynamy & Toxicol, Mashhad, Iran Mashhad Univ Med Sci Mashhad Iran armacodynamy & Toxicol, Mashhad, Iran
Titolo Testata:
JOURNAL OF ETHNOPHARMACOLOGY
fascicolo: 1, volume: 77, anno: 2001,
pagine: 71 - 75
SICI:
0378-8741(200109)77:1<71:EOFGBF>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
PHYSICAL-DEPENDENCE; GUINEA-PIG; RAT; INVOLVEMENT; TOLERANCE; EXTRACT;
Keywords:
Ferula gummosa; morphine dependence; fractionation; diazepam; withdrawal syndrome;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Ramezani, M Mashhad Univ Med Sci, Sch Pharm, Dept Pharmacognosy & Biotechnol, POB 91775-1365, Mashhad, Iran Mashhad Univ Med Sci POB 91775-1365 Mashhad Iran shhad, Iran
Citazione:
M. Ramezani et al., "Effects of Ferula gummosa Boiss. fractions on morphine dependence in mice", J ETHNOPHAR, 77(1), 2001, pp. 71-75

Abstract

Activity-guided fractionation of methanol-chloroform (1:1) extract of Ferula gummosa was carried out to investigate the isolation of the active component(s) responsible for the alleviation of morphine withdrawal syndrome induced by naloxone. Dependence was induced using subcutaneous (s.c.) injections of morphine daily for three days. On day 4, morphine was injected 0.5 h before the interaperitoneal (i.p.) injections of fractions or diazepam (5 mg/kg, i.p.) as positive control. Naloxone was injected (5 mg/kg, s.c.) 2 h after the final dose of morphine. The number of episodes of jumping during 30 min after the injection of naloxone was considered as the intensity of the withdrawal syndrome. The methanol-chloroform (1:1) extract of the aerialparts of plant was prepared and partitioned between water and chloroform. The active chloroform layer was concentrated and partitioned between methanol-water (9:1) and n-hexane. Activity was observed in the hydroalcoholic layer. This layer was concentrated and partitioned further between methanol-water (3:2) and chloroform. The chloroform layer showed a dose-dependent andsignificant activity. For ail fractions the activity was observed at 470 mg/kg. Further purification on silica gel column chromatography gave a pure compound, which was 10 times as effective as the crude extract. The resultsof this study indicated that the plant extract contained component(s) thatcould be useful for the alleviation of morphine withdrawal syndrome. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/05/20 alle ore 12:47:45