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Titolo:
Transport of nanoparticles across the rat nasal mucosa
Autore:
Brooking, J; Davis, SS; Illum, L;
Indirizzi:
Univ Nottingham, Inst Pharmaceut Sci, Nottingham NG7 2RD, England Univ Nottingham Nottingham England NG7 2RD , Nottingham NG7 2RD, England Albert Einstein Ctr, Drug Delivery & Clin Res Ctr Ltd, W Pharmaceut Serv, Nottingham NG7 2TN, England Albert Einstein Ctr Nottingham England NG7 2TN ttingham NG7 2TN, England
Titolo Testata:
JOURNAL OF DRUG TARGETING
fascicolo: 4, volume: 9, anno: 2001,
pagine: 267 - 279
SICI:
1061-186X(2001)9:4<267:TONATR>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMMUNODEFICIENCY-VIRUS TYPE-1; IMMUNE-RESPONSES; NONHUMAN-PRIMATES; INTRANASAL IMMUNIZATION; POLYSTYRENE PARTICLES; LYMPHOID-TISSUE; DNA INOCULATION; GENE DELIVERY; PLASMID DNA; CHITOSAN;
Keywords:
nanoparticles; polystyrene; NALT; nasal delivery; chitosan; gene delivery;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Illum, L Univ Nottingham, Inst Pharmaceut Sci, Boots Sci Bldg,Sci Rd,Univ Pk, Nottingham NG7 2RD, England Univ Nottingham Boots Sci Bldg,Sci Rd,Univ Pk Nottingham England NG7 2RD
Citazione:
J. Brooking et al., "Transport of nanoparticles across the rat nasal mucosa", J DRUG TAR, 9(4), 2001, pp. 267-279

Abstract

The transport of I-125-radiolabelled latex nanoparticles across the nasal mucosa of rats was studied using a range of particle sizes and surface coatings. Translocation of the particles into the blood stream was examined by means of monitoring the radiolabel associated with the particles. Particleswere detected in the blood after 5 minutes. The number of particles in theblood peaked at 60 minutes, and then remained constant for a further 2 hours. The smallest particles (20 nm) showed greater uptake than the largest particles investigated (1000 nm). The total maximum uptake seen for the smallest particles was in the order of 3.25% of administered dose. 100 mn particles coated with chitosan showed an increase in both the extent and rate ofuptake, with the concentration in the blood peaking at 15 minutes rather than at 60 minutes. It is suggested that transport of the particles across the nasal membrane is due mainly to a transcellular transport mechanisms by the nasal associated lymphoid tissue (NALT), especially the M-cell like cells. However, some paracellular transport cannot totally be ruled out for the smallest particles, especially if coated with chitosan.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 04:48:07