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Titolo:
Porphyromonas gingivalis - Specific IgG subclass antibody levels as immunological risk indicators of periodontal bone loss
Autore:
Sakai, Y; Shimauchi, H; Ito, HO; Okada, H;
Indirizzi:
Tohoku Univ, Grad Sch Dent, Div Periodont & Endodont, Aoba Ku, Sendai, Miyagi 9808575, Japan Tohoku Univ Sendai Miyagi Japan 9808575 Ku, Sendai, Miyagi 9808575, Japan Osaka Univ, Grad Sch Dent, Div Periodontol, Suita, Osaka 5650871, Japan Osaka Univ Suita Osaka Japan 5650871 odontol, Suita, Osaka 5650871, Japan Kagoshima Univ, Dept Prevent Dent, Sch Dent, Kagoshima 8908544, Japan Kagoshima Univ Kagoshima Japan 8908544 ch Dent, Kagoshima 8908544, Japan
Titolo Testata:
JOURNAL OF CLINICAL PERIODONTOLOGY
fascicolo: 9, volume: 28, anno: 2001,
pagine: 853 - 859
SICI:
0303-6979(200109)28:9<853:PG-SIS>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
SERUM IGG; ACTINOBACILLUS-ACTINOMYCETEMCOMITANS; BACTEROIDES-GINGIVALIS; PSEUDOMONAS-AERUGINOSA; ADULT PERIODONTITIS; HOST RESPONSE; DISEASE; INDIVIDUALS; DIAGNOSIS; BACTERIA;
Keywords:
Porphyromonas gingivalis; IgG subclass; periodontal bone destruction; risk indicator; supporting periodontal therapy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Shimauchi, H Tohoku Univ, Grad Sch Dent, Div Periodont & Endodont, Aoba Ku, 4-1 Seiryo Machi, Sendai, Miyagi 9808575, Japan Tohoku Univ 4-1 Seiryo Machi Sendai Miyagi Japan 9808575 apan
Citazione:
Y. Sakai et al., "Porphyromonas gingivalis - Specific IgG subclass antibody levels as immunological risk indicators of periodontal bone loss", J CLIN PER, 28(9), 2001, pp. 853-859

Abstract

Background: It has been well demonstrated a positive association between the magnitude of host antibody response and periodontal disease status. Previous studies also reported that Porphyromonas gingivalis-specific IgG subclass antibodies were elevated in sera from adult periodontitis patients. However, the role and the association of these IgG subclass antibodies to the development of periodontal diseases are poorly understood. Aim: The aim of present investigation was to examine the relation of serumIgG subclass antibody levels and alveolar bone loss in treated and untreated periodontitis patients. Methods: Serum samples were taken from 20 treated and maintained periodontitis patients (SPT patients), 30 untreated patients and 19 periodontally healthy subjects. We determined the IgG subclass antibody titers to P. gingivalis whole cells using an enzyme-linked immunosorbent assay (ELISA). Subgingival plaque samples were taken from the mesio-buccal surface of 6 randomlyselected teeth of SPT patients and evaluated for the presence of P. gingivalis by immunofluorescence microscopy. Clinical measurements were also taken including full mouth intraoral radiographs to measure interproximal alveolar bone loss at baseline (BLSI) and at a 5-year recall visit in the SPT patients (BLS2). Results: Our results indicated that both patient groups had detectable levels of IgG1, IgG2, and IgG4. Significantly higher IgG1 was observed in bothpatient groups compared to the healthy subjects. The untreated patients also exhibited significantly elevated IgG2 response (p <0.05). The mean IgG4 level of the SPT patients was significantly higher compared to the other subject group (p <0.05). A statistically significant positive correlation between IgG2 levels and changes in bone levels (ABLS: BLS2-BLS1) was seen in the SPT patients (p <0.001). SPT patients with high IgG2 and low IgG4 showedgreater bone loss than those with low IgG2 and high IgG4 (p <0.05), although the mean prevalence of P. gingivalis in the 2 groups did not differ significantly. Conclusion: Our data suggest that the prolonged IgG2 response after periodontal treatment may be indicative of recurrent or persistent periodontal destruction.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 06:23:51