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Titolo:
The AP-3-dependent targeting of the melanosomal glycoprotein QNR-71 requires a di-leucine-based sorting signal
Autore:
Le Borgne, R; Planque, N; Martin, P; Dewitte, F; Saule, S; Hoflack, B;
Indirizzi:
Inst Pasteur, CNRS, EP525, Inst Biol, F-59021 Lille, France Inst Pasteur Lille France F-59021 P525, Inst Biol, F-59021 Lille, France
Titolo Testata:
JOURNAL OF CELL SCIENCE
fascicolo: 15, volume: 114, anno: 2001,
pagine: 2831 - 2841
SICI:
0021-9533(200108)114:15<2831:TATOTM>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
HERMANSKY-PUDLAK-SYNDROME; AP-3 ADAPTER COMPLEX; TRANS-GOLGI NETWORK; TUMOR-INFILTRATING LYMPHOCYTES; PIGMENT GRANULE BIOGENESIS; KINASE-II PHOSPHORYLATION; MELANOCYTE-SPECIFIC GENE; STORAGE POOL DEFICIENCY; CYTOPLASMIC TAIL; MEMBRANE-PROTEINS;
Keywords:
AP-3; retina; glycoproteins; sorting; melanosome;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
64
Recensione:
Indirizzi per estratti:
Indirizzo: Hoflack, B Inst Curie, UMR 144, 26 Rue Ulm, F-75248 Paris 5, France Inst Curie 26 Rue Ulm Paris France 5 , F-75248 Paris 5, France
Citazione:
R. Le Borgne et al., "The AP-3-dependent targeting of the melanosomal glycoprotein QNR-71 requires a di-leucine-based sorting signal", J CELL SCI, 114(15), 2001, pp. 2831-2841

Abstract

The Quail Neuroretina clone 71 gene (QNR-71) is expressed during the differentiation of retinal pigmented epithelia and the epidermis. It encodes a type I transmembrane glycoprotein that shares significant sequence homologies with several melanosomal proteins. We have studied its intracellular traffic in both pigmented and non-pigmented cells. We report that a di-leucine-based sorting signal (ExxPLL) present in the cytoplasmic domain of QNR-71 is necessary and sufficient for its proper targeting to the endosomal/premelanosomal compartments of both pigmented and non-pigmented cells. The intracellular transport of QNR-71 to these compartments is mediated by the AP-3 assembly proteins. As previously observed for the lysosomal glycoproteins LampI and LimpII, overexpression of QNR-71 increases the amount of AP-3 associated with membranes, and inhibition of AP-3 synthesis increases the routing of QNR-71 towards the cell surface. In addition, expression of QNR-71 induces a misrouting of endogenous LampI to the cell surface. Thus, the targeting of QNR-71 might be similar to that of the lysosomal integral membrane glycoproteins LampI and LimpII. This suggests that sorting to melanosomes and lysosomes requires similar sorting signals and transport machineries.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 14:26:29