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Titolo:
Rho GTPases and cell migration
Autore:
Ridley, AJ;
Indirizzi:
Royal Free & Univ Coll Sch Med, Ludwig Inst Canc Res, London W1W 7BS, England Royal Free & Univ Coll Sch Med London England W1W 7BS n W1W 7BS, England
Titolo Testata:
JOURNAL OF CELL SCIENCE
fascicolo: 15, volume: 114, anno: 2001,
pagine: 2713 - 2722
SICI:
0021-9533(200108)114:15<2713:RGACM>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTERMEDIATE FILAMENT NETWORK; ACTIN CYTOSKELETAL DYNAMICS; FIBRILLARY ACIDIC PROTEIN; ALDRICH-SYNDROME PROTEIN; GROWTH-FACTOR; STRESS FIBERS; FOCAL ADHESIONS; EXCHANGE FACTOR; FAMILY GTPASES; RAC1 GTPASES;
Keywords:
Rho GTPases; actin; cytoskeleton; migration; cell adhesion;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
144
Recensione:
Indirizzi per estratti:
Indirizzo: Ridley, AJ Royal Free & Univ Coll Sch Med, Ludwig Inst Canc Res, 91 RidingHouse St, London W1W 7BS, England Royal Free & Univ Coll Sch Med 91 RidingHouse St London England W1W 7BS
Citazione:
A.J. Ridley, "Rho GTPases and cell migration", J CELL SCI, 114(15), 2001, pp. 2713-2722

Abstract

Cell migration involves dynamic and spatially regulated changes to the cytoskeleton and cell adhesion. The Rho GTPases play key roles in coordinatingthe cellular responses required for cell migration. Recent research has revealed new molecular links between Rho family proteins and the actin cytoskeleton, showing that they act to regulate actin polymerization, depolymerization and the activity of actin-associated myosins. In addition, studies onintegrin signalling suggest that the substratum continuously feeds signalsto Rho proteins in migrating cells to influence migration rate. There is also increasing evidence that Rho proteins affect the organization of the microtubule and intermediate filament networks and that this is important forcell migration.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 06:34:40