Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Signal transduction in smooth muscle - Invited review: Mechanisms of calcium handling in smooth muscles
Autore:
Sanders, KM;
Indirizzi:
Univ Nevada, Sch Med, Dept Physiol & Cell Biol, Reno, NV 89511 USA Univ Nevada Reno NV USA 89511 ept Physiol & Cell Biol, Reno, NV 89511 USA
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 3, volume: 91, anno: 2001,
pagine: 1438 - 1449
SICI:
8750-7587(200109)91:3<1438:STISM->2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
GUINEA-PIG ILEUM; RAT PORTAL-VEIN; NONSELECTIVE CATION CHANNELS; GATED ION CHANNELS; INOSITOL 1,4,5-TRISPHOSPHATE RECEPTORS; TRANSIENT OUTWARD CURRENTS; SUPERFICIAL BUFFER BARRIER; MITOCHONDRIAL CA2+ UPTAKE; INDUCED INWARD CURRENT; WHOLE-CELL CURRENTS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
120
Recensione:
Indirizzi per estratti:
Indirizzo: Sanders, KM Univ Nevada, Sch Med, Dept Physiol & Cell Biol, Reno, NV 89511USA Univ Nevada Reno NV USA 89511 & Cell Biol, Reno, NV 89511 USA
Citazione:
K.M. Sanders, "Signal transduction in smooth muscle - Invited review: Mechanisms of calcium handling in smooth muscles", J APP PHYSL, 91(3), 2001, pp. 1438-1449

Abstract

The concentration of cytoplasmic Ca2+ regulates the contractile state of smooth muscle cells and tissues. Elevations in global cytoplasmic Ca2+ resulting in contraction are accomplished by Ca2+ entry and release from intracellular stores. Pathways for Ca2+ entry include dihydropyridine-sensitive and -insensitive Ca2+ channels and receptor and store-operated nonselective channels permeable to Ca2+. Intracellular release from the sarcoplasmic reticulum (SR) is accomplished by ryanodine and inositol trisphosphate receptors. The impact of Ca2+ entry and release on cytoplasmic concentration is modulated by Ca2+ reuptake into the SR, uptake into mitochondria, and extrusion into the extracellular solution. Highly localized Ca2+ transients (i.e., sparks and puffs) regulate ionic conductances in the plasma membrane, whichcan provide feedback to cell excitability and affect Ca2+ entry. This short review describes the major transport mechanisms and compartments that areutilized for Ca2+ handling in smooth muscles.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 22:15:20