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Titolo:
Regulation of vocal fold transepithelial water fluxes
Autore:
Fisher, KV; Telser, A; Phillips, JE; Yeates, DB;
Indirizzi:
Northwestern Univ, Dept Commun Sci & Disorders, Evanston, IL 60208 USA Northwestern Univ Evanston IL USA 60208 Disorders, Evanston, IL 60208 USA Univ Illinois, Dept Med, Chicago, IL 60612 USA Univ Illinois Chicago IL USA 60612 inois, Dept Med, Chicago, IL 60612 USA Northwestern Univ, Dept Cell & Mol Biol, Evanston, IL 60208 USA Northwestern Univ Evanston IL USA 60208 Mol Biol, Evanston, IL 60208 USA Vet Affairs Chicago Hlth Care Syst, Chicago, IL 60612 USA Vet Affairs Chicago Hlth Care Syst Chicago IL USA 60612 ago, IL 60612 USA
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 3, volume: 91, anno: 2001,
pagine: 1401 - 1411
SICI:
8750-7587(200109)91:3<1401:ROVFTW>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
BIOELECTRIC PROPERTIES; MUCOCILIARY TRANSPORT; ENDOTHELIAL-CELLS; LOCALIZATION; MECHANISMS; SHEEP; PERMEABILITY; EPITHELIUM; AIRWAYS; SYSTEM;
Keywords:
ion transport; sodium-potassium pump; larynx; voice; dog;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Fisher, KV Northwestern Univ, Dept Commun Sci & Disorders, 2299 N Campus Dr, Evanston, IL 60208 USA Northwestern Univ 2299 N Campus Dr Evanston IL USA 60208 08 USA
Citazione:
K.V. Fisher et al., "Regulation of vocal fold transepithelial water fluxes", J APP PHYSL, 91(3), 2001, pp. 1401-1411

Abstract

Vocal fold hydration is critical to phonation. We hypothesized that the vocal fold generates bidirectional water fluxes, which are regulated by activity of the Na+-K+ ATPase. Western blots and immunohistochemistry demonstrated the presence of the alpha -subunit Na+-K+ -ATPase in the canine vocal fold (n = 11). Luminal cells, basal and adjacent one to two layers of suprabasal cells within stratified squamous epithelium, were immunopositive, as well as basolateral membranes of submucosal seromucous glands underlying transitional epithelia. Canine (n = 6) and ovine (n = 14) vocal fold mucosae exhibited transepithelial potential differences of 8.1 +/-2.8 and 9.3 +/-1.3 mV (lumen negative), respectively. The potential difference and short-circuit current (ovine = 31 +/-4 muA/cm(2); canine = 41 +/- 10 muA/cm(2)) were substantially reduced by luminal administration of 75 muM acetylstrophanthidin (P<0.05). Ovine (n = 7) transepithelial water fluxes decreased from 5.1<plus/minus>0.3 to 4.3 +/-0.3 mul.min(-1).cm(-2) from the basal to luminal chamber and from 5.2 +/-0.2 to 3.9 +/-0.3 mul.min(-1).cm(-2) from the luminal to basal chamber by luminal acetylstrophanthidin (P<0.05). The presence of the Na+-K+ -ATPase in the vocal fold epithelium and the electrolyte transport derived from its activity provide the intrinsic mechanisms to regulatecell volume as well as vocal fold hydration.

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Documento generato il 02/04/20 alle ore 22:03:56