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Titolo:
Distribution and colocalization of neurotransmitters and receptors in the pre-Botzinger complex of rats
Autore:
Liu, YY; Ju, G; Wong-Riley, MTT;
Indirizzi:
Med Coll Wisconsin, Dept Cell Biol Neurobiol & Anat, Milwaukee, WI 53226 USA Med Coll Wisconsin Milwaukee WI USA 53226 & Anat, Milwaukee, WI 53226 USA Fourth Mil Med Univ, Inst Neurosci, Xian 710032, Peoples R China Fourth Mil Med Univ Xian Peoples R China 710032 710032, Peoples R China
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 3, volume: 91, anno: 2001,
pagine: 1387 - 1395
SICI:
8750-7587(200109)91:3<1387:DACONA>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
RESPIRATORY RHYTHM GENERATION; CENTRAL NERVOUS-SYSTEM; AMINO-ACID RECEPTORS; NON-NMDA RECEPTORS; BRAIN-STEM; NITRIC-OXIDE; CYTOCHROME-OXIDASE; PREINSPIRATORY NEURONS; PREBOTZINGER COMPLEX; NEWBORN RATS;
Keywords:
neurokinin-1 receptor; cytochrome oxidase; glutamate; GABA; nitric oxide synthase;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Wong-Riley, MTT Med Coll Wisconsin, Dept Cell Biol Neurobiol & Anat, 8701 Watertown Plank Rd, Milwaukee, WI 53226 USA Med Coll Wisconsin 8701 Watertown Plank Rd Milwaukee WI USA 53226
Citazione:
Y.Y. Liu et al., "Distribution and colocalization of neurotransmitters and receptors in the pre-Botzinger complex of rats", J APP PHYSL, 91(3), 2001, pp. 1387-1395

Abstract

The pre- Botzinger complex (PBC), thought to be the center of respiratory rhythm generation, is a cell column ventrolateral to the nucleus ambiguus. The present study analyzed its cellular and neurochemical composition in adult rats. PBC neurons were mainly oval, fusiform, or multipolar in shape and small to medium in size. Neurokinin-1 receptor, a marker of the PBC, was present in the plasma membrane of mostly medium and small neurons and theirassociated processes and boutons. Among neurons immunoreactive for different neurotransmitter or receptor candidates, various numbers were colocalized with neurokinin-1 receptor. The highest ratio was with nitric oxide synthase (52.72%), and the lowest was with glycine receptors (31.93%). Glutamic acid decarboxylase- and glycine transporter 2-immunoreactive boutons, as well as GABAA receptor-immunoreactive plasma membrane processes and boutons, were also identified in the PBC. PBC neurons exhibited different levels of cytochrome oxidase activity, indicating their various energy demands. Our results suggest that synaptic interactions within the PBC of adult rats involve a variety of neurotransmitter and receptor types and that nitric oxide may play an important role in addition to glutamate, GABA, glycine, and neurokinin.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 18:32:13