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Titolo:
Genetic selection of mice for high voluntary wheel running: effect on skeletal muscle glucose uptake
Autore:
Dumke, CL; Rhodes, JS; Garland, T; Maslowski, E; Swallow, JG; Wetter, AC; Cartee, GD;
Indirizzi:
Univ Wisconsin, Dept Kinesiol, Biodynam Lab, Madison, WI 53706 USA Univ Wisconsin Madison WI USA 53706 , Biodynam Lab, Madison, WI 53706 USA Univ Wisconsin, Dept Zool, Madison, WI 53706 USA Univ Wisconsin Madison WI USA 53706 sin, Dept Zool, Madison, WI 53706 USA Univ Wisconsin, Dept Nutr Sci, Madison, WI 53706 USA Univ Wisconsin Madison WI USA 53706 Dept Nutr Sci, Madison, WI 53706 USA
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 3, volume: 91, anno: 2001,
pagine: 1289 - 1297
SICI:
8750-7587(200109)91:3<1289:GSOMFH>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
IN-HOUSE MICE; ENHANCED INSULIN SENSITIVITY; OBESE ZUCKER RATS; GLYCOGEN SUPERCOMPENSATION; ARTIFICIAL SELECTION; TRANSPORT ACTIVITY; KNOCKOUT MICE; EXERCISE; RESISTANCE; METABOLISM;
Keywords:
glucose transport; exercise; artificial selection; insulin sensitivity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Cartee, GD Univ Wisconsin, Dept Kinesiol, Biodynam Lab, 2000 Observ Dr, Madison, WI 53706 USA Univ Wisconsin 2000 Observ Dr Madison WI USA 53706 WI 53706 USA
Citazione:
C.L. Dumke et al., "Genetic selection of mice for high voluntary wheel running: effect on skeletal muscle glucose uptake", J APP PHYSL, 91(3), 2001, pp. 1289-1297

Abstract

Effects of genetic selection for high wheel-running activity (17th generation) and access to running wheels on skeletal muscle glucose uptake were studied in mice with the following treatments for 8 wk: 1) access to unlockedwheels; 2) same as 1, but wheels locked 48 h before glucose uptake measurement; or 3) wheels always locked. Selected mice ran more than random-bred (nonselected) mice (8-wk mean +/- SE 5 8,243 +/- 711 vs. 3,719 +/- 233 revolutions/day). Body weight was 5-13% lower for selected vs. nonselected groups. Fat pad/body weight was similar to 40% lower for selected vs. nonselected and unlocked vs. locked groups. Insulin-stimulated glucose uptake and fatpad/body weight were inversely correlated for isolated soleus (r = 0.333; P< 0.005) but not extensor digitorum longus (EDL) or epitrochlearis muscles. Insulin-stimulated glucose uptake was higher in EDL (P< 0.02) for selected vs. nonselected mice. Glucose uptake did not differ by wheel group, and amount of running did not correlate with glucose uptake for any muscle. Wheel running by mice did not enhance subsequent glucose uptake by isolated muscles.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 10:01:22