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Titolo:
Effect of Rho-kinase inhibition on vasoconstriction in the penile circulation
Autore:
Mills, TM; Chitaley, K; Wingard, CJ; Lewis, RW; Webb, RC;
Indirizzi:
Med Coll Georgia, Dept Physiol, Augusta, GA 30912 USA Med Coll Georgia Augusta GA USA 30912 Dept Physiol, Augusta, GA 30912 USA Med Coll Georgia, Dept Surg, Urol Sect, Augusta, GA 30912 USA Med Coll Georgia Augusta GA USA 30912 g, Urol Sect, Augusta, GA 30912 USA
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 3, volume: 91, anno: 2001,
pagine: 1269 - 1273
SICI:
8750-7587(200109)91:3<1269:EORIOV>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
VASCULAR SMOOTH-MUSCLE; CORPUS CAVERNOSUM; ERECTILE FUNCTION; PROTEIN-KINASE; RAT; SENSITIZATION; CONTRACTION; PHYSIOLOGY;
Keywords:
penile erection; vasodilation; penis; methoxamine; endothelin-1;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Mills, TM Med Coll Georgia, Dept Physiol, Augusta, GA 30912 USA Med Coll Georgia Augusta GA USA 30912 ol, Augusta, GA 30912 USA
Citazione:
T.M. Mills et al., "Effect of Rho-kinase inhibition on vasoconstriction in the penile circulation", J APP PHYSL, 91(3), 2001, pp. 1269-1273

Abstract

A recent report from this laboratory (Chitaley K, Wingard C, Webb R, Branam H, Stopper V, Lewis R, and Mills T. Nature Medicine 7: 119-122, 2001) showed that inhibition of Rho-kinase increased the erectile response (intracavernosal pressure and mean arterial pressure) by a process that does not require nitric oxide or cGMP. The present study investigated whether vasoconstrictor agents, which are active in the penis, act via the Rho-kinase pathway. Western analysis revealed RhoA and Rho-kinase protein in the penis. Treatment with the selective Rho-kinase inhibitor Y-27632 significantly increased the magnitude of the erectile response. Intracavernous administration ofendothelin-1 (ET-1; 50 pmol) or methoxamine (10 mug/kg) reduced the erectile response to autonomic stimulation. If Y-27632 was given before ET-1 or methoxamine, the vasoconstrictor effect was reduced, and intracavernosal pressure and mean arterial pressure remained elevated. However, when given after methoxamine, Y-27632 had a reduced vasodilatory effect, and Y-27632 had no vasodilatory effect when given after ET-1. These findings suggest that ET-1 and methoxamine increase Rho-kinase activity in the cavernous circulation and support the hypothesis that the vasoconstriction that maintains the penis in the nonerect state is mediated, in part, by the Rho-kinase pathway.

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Documento generato il 23/01/21 alle ore 03:46:07