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Titolo:
Glucose uptake and metabolic stress in rat muscles stimulated electricallywith different protocols
Autore:
Aslesen, R; Engebretsen, EML; Franch, J; Jensen, J;
Indirizzi:
Natl Inst Occupat Hlth, Dept Physiol, N-0033 Oslo, Norway Natl Inst Occupat Hlth Oslo Norway N-0033 t Physiol, N-0033 Oslo, Norway Norwegian Univ Sport & Phys Educ, N-0806 Oslo, Norway Norwegian Univ Sport& Phys Educ Oslo Norway N-0806 N-0806 Oslo, Norway Univ Oslo, Inst Basic Med Sci, Dept Anat, N-0317 Oslo, Norway Univ Oslo Oslo Norway N-0317 sic Med Sci, Dept Anat, N-0317 Oslo, Norway Odense Univ, Inst Sport Sci & Phys Educ, DK-5230 Odense, Denmark Odense Univ Odense Denmark DK-5230 & Phys Educ, DK-5230 Odense, Denmark
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 3, volume: 91, anno: 2001,
pagine: 1237 - 1244
SICI:
8750-7587(200109)91:3<1237:GUAMSI>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACTIVATED PROTEIN-KINASE; SKELETAL-MUSCLE; EPITROCHLEARIS MUSCLE; GLYCOGEN-CONTENT; SENSITIVE POOL; TRANSPORT; CONTRACTION; INSULIN; EXERCISE; IDENTIFICATION;
Keywords:
glycogen; adenosine 5 '-triphosphate; force; fiber type; fatigue;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Jensen, J Natl Inst Occupat Hlth, Dept Physiol, POB 8149, N-0033 Oslo, Norway Natl Inst Occupat Hlth POB 8149 Oslo Norway N-0033 Oslo, Norway
Citazione:
R. Aslesen et al., "Glucose uptake and metabolic stress in rat muscles stimulated electricallywith different protocols", J APP PHYSL, 91(3), 2001, pp. 1237-1244

Abstract

In the present study, the relationship between the pattern of electrical stimulation and glucose uptake was investigated in slow-twitch muscles (soleus) and fast-twitch muscles (epitrochlearis) from Wistar rats. Muscles werestimulated electrically for 30 min in vitro with either single pulses (frequencies varied between 0.8 and 15 Hz) or with 200-ms trains (0.1-2 Hz). Glucose uptake (measured with tracer amount of 2-[H-3] deoxyglucose) increased with increasing number of impulses whether delivered as single pulses or as short trains. The highest glucose uptake achieved with short tetanic contractions was similar in soleus and epitrochlearis (10.9 +/- 0.7 and 12.0 +/- 0.8 mmol.kg dry wt(-1).30 min(-1), respectively). Single pulses, on the other hand, increased contraction-stimulated glucose uptake less in soleus than in epitrochlearis (7.5 +/- 1.1 and 11.7 +/- 0.5 mmol.kg dry wt(-1).30 min(-1), respectively; P< 0.02). Glucose uptake correlated with glycogen breakdown in soleus (r = 0.84, P< 0.0001) and (epitrochlearis: r = 0.91, P< 0.0001). Contraction-stimulated glucose uptake also correlated with breakdown of ATP and PCr and with reduction in force. Our data suggest that metabolic stress mediates contraction-stimulated glucose uptake.

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Documento generato il 29/03/20 alle ore 12:13:10