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Titolo:
Increased renal tubular sodium reabsorption during exercise-induced hypervolemia in humans
Autore:
Nagashima, K; Wu, JC; Kavouras, SA; Mack, GW;
Indirizzi:
Yale Univ, Sch Med, John B Pierce Lab, New Haven, CT 06519 USA Yale Univ New Haven CT USA 06519 hn B Pierce Lab, New Haven, CT 06519 USA Yale Univ, Sch Med, Dept Epidemiol & Publ Hlth, New Haven, CT 06519 USA Yale Univ New Haven CT USA 06519 iol & Publ Hlth, New Haven, CT 06519 USA
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 3, volume: 91, anno: 2001,
pagine: 1229 - 1236
SICI:
8750-7587(200109)91:3<1229:IRTSRD>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
SYMPATHETIC-NERVE ACTIVITY; LITHIUM CLEARANCE; PLASMA-VOLUME; POSTEXERCISE HYPOTENSION; ALBUMIN SYNTHESIS; SALT INTAKE; BLOOD-FLOW; SYMPATHOINHIBITION; HYPERTENSION; EXPANSION;
Keywords:
lithium clearance; renal function; colloid osmotic pressure; renal blood flow;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Mack, GW Yale Univ, Sch Med, John B Pierce Lab, 290 Congress Ave, New Haven, CT 06519 USA Yale Univ 290 Congress Ave New Haven CT USA 06519 n, CT 06519 USA
Citazione:
K. Nagashima et al., "Increased renal tubular sodium reabsorption during exercise-induced hypervolemia in humans", J APP PHYSL, 91(3), 2001, pp. 1229-1236

Abstract

We tested the hypothesis that renal tubular Na+ reabsorption increased during the first 24 h of exercise-induced plasma volume expansion. Renal function was assessed 1 day after no-exercise control (C) or intermittent cycle ergometer exercise (Ex, 85% of peak O-2 uptake) for 2 h before and 3 h after saline loading (12.5 ml/kg over 30 min) in seven subjects. Ex reduced renal blood flow (p-aminohippurate clearance) compared with C (0.83 +/- 0.12 vs. 1.49 +/- 0.24 l/min, P< 0.05) but did not influence glomerular filtration rates (97 +/- 10 ml/min, inulin clearance). Fractional tubular reabsorption of Na+ in the proximal tubules was higher in Ex than in C (P< 0.05). Saline loading decreased fractional tubular reabsorption of Na+ from 99.1 +/- 0.1 to 98.7 +/- 0.1% (P< 0.05) in C but not in Ex (99.3 +/- 0.1 to 99.4 +/-0.1%). Saline loading reduced plasma renin activity and plasma arginine vasopressin levels in C and Ex, although the magnitude of decrease was greater in C (P< 0.05). These results indicate that, during the acute phase of exercise-induced plasma volume expansion, increased tubular Na+ reabsorption is directed primarily to the proximal tubules and is associated with a decrease in renal blood flow. In addition, saline infusion caused a smaller reduction in fluid-regulating hormones in Ex. The attenuated volume-regulatoryresponse acts to preserve distal tubular Na+ reabsorption during saline infusion 24 h after exercise.

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Documento generato il 01/04/20 alle ore 11:44:14