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Titolo:
Effect of short-term microgravity and long-term hindlimb unloading on rat cardiac mass and function
Autore:
Ray, CA; Vasques, M; Miller, TA; Wilkerson, MK; Delp, MD;
Indirizzi:
Penn State Univ, Milton S Hershey Med Ctr, Coll Med, Div Cardiol H047,DeptMed, Hershey, PA 17033 USA Penn State Univ Hershey PA USA 17033 H047,DeptMed, Hershey, PA 17033 USA Penn State Univ, Coll Med, Dept Cellular & Mol Physiol, Hershey, PA 17033 USA Penn State Univ Hershey PA USA 17033 & Mol Physiol, Hershey, PA 17033 USA NASA, Ames Res Ctr, Div Life Sci, Moffett Field, CA 94035 USA NASA Moffett Field CA USA 94035 Div Life Sci, Moffett Field, CA 94035 USA Texas A&M Univ, Dept Hlth & Kinesiol, College Stn, TX 77843 USA Texas A&M Univ College Stn TX USA 77843 nesiol, College Stn, TX 77843 USA Texas A&M Univ, Hlth Sci Ctr, Dept Med Physiol, College Stn, TX 77843 USA Texas A&M Univ College Stn TX USA 77843 hysiol, College Stn, TX 77843 USA Texas A&M Univ, Hlth Sci Ctr, Cardiovasc Res Inst, College Stn, TX 77843 USA Texas A&M Univ College Stn TX USA 77843 s Inst, College Stn, TX 77843 USA
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 3, volume: 91, anno: 2001,
pagine: 1207 - 1213
SICI:
8750-7587(200109)91:3<1207:EOSMAL>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEAD-DOWN SUSPENSION; SIMULATED MICROGRAVITY; BLOOD-FLOW; ECHOCARDIOGRAPHIC EVALUATION; ORTHOSTATIC INTOLERANCE; CHEMICAL SYMPATHECTOMY; BED-REST; SPACEFLIGHT; PRESSURE; EXERCISE;
Keywords:
heart; deconditioning; cardiac atrophy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Ray, CA Penn State Univ, Milton S Hershey Med Ctr, Coll Med, Div Cardiol H047,DeptMed, Hershey, PA 17033 USA Penn State Univ Hershey PA USA 17033 ptMed, Hershey, PA 17033 USA
Citazione:
C.A. Ray et al., "Effect of short-term microgravity and long-term hindlimb unloading on rat cardiac mass and function", J APP PHYSL, 91(3), 2001, pp. 1207-1213

Abstract

The purpose of this study was to test the hypothesis that exposure to short-term microgravity or long-term hindlimb unloading induces cardiac atrophyin male Sprague-Dawley rats. For the microgravity study, rats were subdivided into four groups: preflight (PF, n = 12); flight (Fl, n = 7); flight cage simulation (Sim, n = 6), and vivarium control (Viv, n = 7). Animals in the Fl group were exposed to 7 days of microgravity during the Spacelab 3 mission. Animals in the hindlimb-unloading study were subdivided into three groups: control (Con, n = 20), 7-day hindlimb-unloaded (7HU, n = 10), and 28-day hindlimb-unloaded (28HU, n = 19). Heart mass was unchanged in adult animals exposed to 7 days of actual microgravity (PF 1.33 +/- 0.03 g; Fl 1.32+/- 0.02 g; Sim 1.28 +/- 0.04 g; Viv 1.35 +/- 0.04 g). Similarly, heart mass was unaltered with hindlimb unloading (Con 1.40 +/- 0.04 g; 7HU 1.35 +/-0.06 g; 28HU 1.42 +/- 0.03 g). Hindlimb unloading also had no effect on the peak rate of rise in left ventricular pressure, an estimate of myocardialcontractility (Con 8,055 +/- 385 mmHg/s; 28HU 8,545 +/- 755 mmHg/s). Thesedata suggest that cardiac atrophy does not occur after short-term exposureto microgravity and that neither short- nor long-term simulated microgravity alters cardiac mass or function.

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Documento generato il 18/01/21 alle ore 16:11:07