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Titolo:
Airway stability and heterogeneity in the constricted lung
Autore:
Anafi, RC; Wilson, TA;
Indirizzi:
Univ Minnesota, Dept Aerosp Engn & Mech, Minneapolis, MN 55455 USA Univ Minnesota Minneapolis MN USA 55455 & Mech, Minneapolis, MN 55455 USA
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 3, volume: 91, anno: 2001,
pagine: 1185 - 1192
SICI:
8750-7587(200109)91:3<1185:ASAHIT>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
SMOOTH-MUSCLE; INTRAVENOUS HISTAMINE; PRESSURE-VOLUME; TIDAL VOLUME; DOG LOBES; ASTHMA; MODEL; INTERDEPENDENCE; RESPONSIVENESS; METHACHOLINE;
Keywords:
airway mechanics; lung resistance; lung elastance; mathematical model;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Wilson, TA 107 Akerman Hall,110 Union St SE, Minneapolis, MN 55455 USA 107 Akerman Hall,110 Union St SE Minneapolis MN USA 55455 USA
Citazione:
R.C. Anafi e T.A. Wilson, "Airway stability and heterogeneity in the constricted lung", J APP PHYSL, 91(3), 2001, pp. 1185-1192

Abstract

The effect of bronchoconstriction on airway resistance is known to be spatially heterogeneous and dependent on tidal volume. We present a model of a single terminal airway that explains these features. The model describes a feedback between flow and airway resistance mediated by parenchymal interdependence and the mechanics of activated smooth muscle. The pressure-tidal volume relationship for a constricted terminal airway is computed and shown to be sigmoidal. Constricted terminal airways are predicted to have two stable states: one effectively open and one nearly closed. We argue that the heterogeneity of whole lung constriction is a consequence of this behavior. Airways are partitioned between the two states to accommodate total flow, and changes in tidal volume and end-expiratory pressure affect the number ofairways in each state. Quantitative predictions for whole lung resistance and elastance agree with data from previously published studies on lung impedance.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 11:01:20