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Titolo:
Skeletal muscle capillarity and angiogenic mRNA levels after exercise training in normoxia and chronic hypoxia
Autore:
Olfert, IM; Breen, EC; Mathieu-Costello, O; Wagner, PD;
Indirizzi:
Loma Linda Univ, Dept Physiol & Pharmacol, Loma Linda, CA 92350 USA Loma Linda Univ Loma Linda CA USA 92350 armacol, Loma Linda, CA 92350 USA Univ Calif San Diego, Dept Med, Div Physiol, La Jolla, CA 92093 USA Univ Calif San Diego La Jolla CA USA 92093 hysiol, La Jolla, CA 92093 USA
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 3, volume: 91, anno: 2001,
pagine: 1176 - 1184
SICI:
8750-7587(200109)91:3<1176:SMCAAM>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOTHELIAL GROWTH-FACTOR; FACTOR MESSENGER-RNA; OXIDE SYNTHASE INHIBITION; VEGF GENE-EXPRESSION; INDUCIBLE FACTOR-1; RESPONSES; FLT-1; RATS; CONTRACTION; ADAPTATION;
Keywords:
Northern blot analysis; angiogenesis; transforming growth factor-beta 1; basic fibroblast growth factor; flt-1; flk-1;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Olfert, IM Univ Calif San Diego, Dept Med 0623A, 9500 Gilman Dr, La Jolla,CA 92093 USA Univ Calif San Diego 9500 Gilman Dr La Jolla CA USA 92093 3 USA
Citazione:
I.M. Olfert et al., "Skeletal muscle capillarity and angiogenic mRNA levels after exercise training in normoxia and chronic hypoxia", J APP PHYSL, 91(3), 2001, pp. 1176-1184

Abstract

Gene expression of vascular endothelial growth factor (VEGF), and to a lesser extent of transforming growth factor-beta (1) (TGF-beta (1)) and basic fibroblast growth factor (bFGF), has been found to increase in rat skeletalmuscle after a single exercise bout. In addition, acute hypoxia augments the VEGF mRNA response to exercise, which suggests that, if VEGF is important in muscle angiogenesis, hypoxic training might produce greater capillary growth than normoxic training. Therefore, we examined the effects of exercise training (treadmill running at the same absolute intensity) in normoxia and hypoxia (inspired O-2 fraction = 0.12) on rat skeletal muscle capillarity and on resting and postexercise gene expression of VEGF, its major receptors (flt-1 and flk-1), TGF-beta (1), and bFGF. Normoxic training did not alter basal or exercise-induced VEGF mRNA levels but produced a modest twofold increase in bFGF mRNA (P < 0.05). Rats trained in hypoxia exhibited an attenuated VEGF mRNA response to exercise (1.8-fold compared 3.4-fold with normoxic training; P < 0.05), absent TGF-beta (1) and flt-1 mRNA responses to exercise, and an approximately threefold (P < 0.05) decrease in bFGF mRNAlevels. flk-1 mRNA levels were not significantly altered by either normoxic or hypoxic training. An increase in skeletal muscle capillarity was observed only in hypoxically trained rats. These data show that, whereas training in hypoxia potentiates the adaptive angiogenic response of skeletal muscle to a given absolute intensity of exercise, this was not evident in the gene expression of VEGF or its receptors when assessed at the end of training.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 19:29:34