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Titolo:
Nitric oxide synthase inhibition does not affect the exercise-induced arterial hypoxemia in Thoroughbred horses
Autore:
Manohar, M; Goetz, TE; Hassan, AS;
Indirizzi:
Univ Illinois, Coll Vet Med, Dept Vet Biosci, Urbana, IL 61801 USA Univ Illinois Urbana IL USA 61801 , Dept Vet Biosci, Urbana, IL 61801 USA Univ Illinois, Coll Vet Med, Dept Clin Med, Urbana, IL 61801 USA Univ Illinois Urbana IL USA 61801 ed, Dept Clin Med, Urbana, IL 61801 USA
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 3, volume: 91, anno: 2001,
pagine: 1105 - 1112
SICI:
8750-7587(200109)91:3<1105:NOSIDN>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED PULMONARY HEMORRHAGE; VASCULAR PRESSURES; GAS-EXCHANGE; L-NAME; RACEHORSES;
Keywords:
arterial blood-gas tensions in exercise; N-omega-nitro-L-arginine methyl ester; exertion;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Manohar, M Univ Illinois, Coll Vet Med, Dept Vet Biosci, 1102 W Hazelwood Dr, Urbana,IL 61802 USA Univ Illinois 1102 W Hazelwood Dr Urbana IL USA 61802 61802 USA
Citazione:
M. Manohar et al., "Nitric oxide synthase inhibition does not affect the exercise-induced arterial hypoxemia in Thoroughbred horses", J APP PHYSL, 91(3), 2001, pp. 1105-1112

Abstract

Because sensitivity of equine pulmonary vasculature to endogenous as well as exogenous nitric oxide (NO) has been demonstrated, we examined whether endogenous NO production plays a role in exercise-induced arterial hypoxemia. We hypothesized that inhibition of NO synthase may alter the distributionof ventilation-perfusion mismatching, which may affect the exercise-induced arterial hypoxemia. Arterial blood-gas variables were examined in seven healthy, sound Thoroughbred horses at rest and during incremental exercise protocol leading to galloping at maximal heart rate without (control; placebo = saline) and with N-omega-nitro-L-arginine methyl ester (L-NAME) administration (20 mg/kg iv). The experiments were carried out in random order, 7 days apart. At rest, L-NAME administration caused systemic hypertension, pulmonary hypertension, and bradycardia. During 120 s of galloping at maximalheart rate, significant arterial hypoxemia, desaturation of hemoglobin, hypercapnia, hyperthermia, and acidosis occurred in the control as well as inNO synthase inhibition experiments. However, statistically significant differences between the treatments were not found. In both treatments, exercise caused a significant rise in hemoglobin concentration, but the increment was significantly attenuated in the NO synthase inhibition experiments, and, therefore, arterial O-2 content (Ca-O2) increased to significantly lower values. These data suggest that, whereas L-NAME administration does not affect pulmonary gas exchange in exercising horses, it may affect splenic contraction, which via an attenuation of the rise in hemoglobin concentration and Ca-O2 may limit performance at higher workloads.

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Documento generato il 26/01/21 alle ore 04:02:48