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Titolo:
Elevating dietary salt exacerbates hyperpnea-induced airway obstruction inguinea pigs
Autore:
Mickleborough, TD; Gotshall, RW; Rhodes, J; Tucker, A; Cordain, L;
Indirizzi:
Univ Wales Coll Cardiff, Inst Cardiff, Sch Sport Sci Phys Educ & Recreat, Cardiff CF23 6XD, S Glam, Wales Univ Wales Coll Cardiff Cardiff S Glam Wales CF23 6XD 6XD, S Glam, Wales Colorado State Univ, Dept Exercise & Hlth Sci, Ft Collins, CO 80523 USA Colorado State Univ Ft Collins CO USA 80523 Sci, Ft Collins, CO 80523 USA Colorado State Univ, Dept Physiol, Ft Collins, CO 80523 USA Colorado StateUniv Ft Collins CO USA 80523 iol, Ft Collins, CO 80523 USA
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 3, volume: 91, anno: 2001,
pagine: 1061 - 1066
SICI:
8750-7587(200109)91:3<1061:EDSEHA>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
DRY GAS HYPERPNEA; EXERCISE-INDUCED BRONCHOSPASM; THERMALLY-INDUCED ASTHMA; INDUCED BRONCHOCONSTRICTION; ISOCAPNIC HYPERPNEA; BRONCHIAL REACTIVITY; SUBSTANCE-P; RESPONSES; TACHYKININS; HISTAMINE;
Keywords:
exercise-induced asthma; sodium chloride; eicosanoids;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Mickleborough, TD Univ Wales Coll Cardiff, Inst Cardiff, Sch Sport Sci Phys Educ & Recreat, Cyncoed Campus,Cyncoed Rd, Cardiff CF23 6XD, S Glam, Wales Univ Wales Coll Cardiff Cyncoed Campus,Cyncoed Rd Cardiff S Glam Wales CF23 6XD
Citazione:
T.D. Mickleborough et al., "Elevating dietary salt exacerbates hyperpnea-induced airway obstruction inguinea pigs", J APP PHYSL, 91(3), 2001, pp. 1061-1066

Abstract

Previous studies have indicated that increased dietary salt consumption worsens postexercise pulmonary function in humans with exercise-induced asthma (EIA). It has been suggested that EIA and hyperpnea-induced airway obstruction (HIAO) in guinea pigs (an animal model of EIA) are mediated by similar mechanisms. Therefore, the purpose of this study was to determine whetheraltering dietary salt consumption also exacerbated HIAO in guinea pigs. Furthermore, the potential pathway of action of dietary salt was investigatedby blocking leukotriene (LT) production during HIAO in guinea pigs. Thirty-two male Hartley strain guinea pigs were split into two groups. One group (n = 16) of animals ingested a normal-salt diet (NSD) for 2 wk; the other group (n = 16) ingested a high-salt diet (HSD) for 2 wk. Thereafter, animalswere anesthetized, cannulated, tracheotomized, and mechanically ventilatedduring a baseline period and during two dry gas hyperpnea challenges. After the first challenge, the animals were administered either saline or nordihydroguaiaretic acid, a LT inhibitor. Bladder urine was analyzed for electrolyte concentrations and urinary LTE4. The HSD elicited higher airway inspiratory pressures (Ptr) than the NSD (P < 0.001) postchallenge. However, after infusion of the LT inhibitor and a second hyperpnea challenge, HIAO was blocked in both diet groups (P < 0.001). Nonetheless, the HSD group continued to demonstrate slightly higher Ptr than the NSD group (P < 0.05). Urinary LTE4 excretion significantly increased in the HSD group compared with theNSD group within treatment groups. This study has demonstrated that dietary salt loading exacerbated the development of HIAO in guinea pigs and that LT release was involved in HIAO and may be moderated by changes in dietary salt loading.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/10/20 alle ore 10:10:52