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Titolo:
Dendritic cells transduced with HIV Nef express normal levels of HLA-A andHLA-B Class I molecules
Autore:
Cramer, LA; Frelinger, JA;
Indirizzi:
Univ N Carolina, Dept Microbiol & Immunol, Chapel Hill, NC 27599 USA Univ N Carolina Chapel Hill NC USA 27599 munol, Chapel Hill, NC 27599 USA
Titolo Testata:
JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
fascicolo: 5, volume: 27, anno: 2001,
pagine: 417 - 425
SICI:
1525-4135(20010815)27:5<417:DCTWHN>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-IMMUNODEFICIENCY-VIRUS; CD4 DOWN-REGULATION; T-CELLS; MONOCLONAL-ANTIBODY; GENE-TRANSFER; MHC-I; RECOMBINANT ADENOVIRUS; TYPE-1; REPLICATION; PROTEIN;
Keywords:
HIV-Nef; dendritic cell; adenovirus;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
54
Recensione:
Indirizzi per estratti:
Indirizzo: Frelinger, JA Univ N Carolina, Dept Microbiol & Immunol, CB 7290 MEJB, Chapel Hill, NC 27599 USA Univ N Carolina CB 7290 MEJB Chapel Hill NC USA 27599 99 USA
Citazione:
L.A. Cramer e J.A. Frelinger, "Dendritic cells transduced with HIV Nef express normal levels of HLA-A andHLA-B Class I molecules", J ACQ IMM D, 27(5), 2001, pp. 417-425

Abstract

HIV Nef protein is important for viral pathogenesis and disease progression. Nef downregulates CD4 and major histocompatibility antigens on the surface of HIV-infected T cells. HIV also infects dendritic cells. We wanted to determine if Nef had a similar function in professional anti gen-presentingcells, where downregulation of Class I could have important effects on theinitiation of HIV specific cytolytic T cell responses. We infected human dendritic cells with adenovirus expressing Nef. In contrast to T cells and Hela cells, HLA-A and HLA-B molecules are not downregulated nor are other class I molecules increased. We show that, in dendritic cells, HIV Nef has little effect on CD4 or Class I expression.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/02/20 alle ore 14:02:29