Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Involvement of beta(2)-adrenergic and mu-opioid receptors in antinociception produced by intracerebroventricular administration of alpha,beta-methylene-ATP
Autore:
Fukui, M; Nakagawa, T; Minami, M; Satoh, M;
Indirizzi:
Kyoto Univ, Fac Pharmaceut Sci, Dept Mol Pharmacol, Kyoto 6068501, Japan Kyoto Univ Kyoto Japan 6068501 Dept Mol Pharmacol, Kyoto 6068501, Japan
Titolo Testata:
JAPANESE JOURNAL OF PHARMACOLOGY
fascicolo: 4, volume: 86, anno: 2001,
pagine: 423 - 428
SICI:
0021-5198(200108)86:4<423:IOBAMR>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOCUS-CERULEUS NEURONS; ADENOSINE 5'-TRIPHOSPHATE; SPINAL-CORD; RAT; ATP; RELEASE; MICRODIALYSIS; TRANSMISSION; BUTORPHANOL; ACTIVATION;
Keywords:
alpha,beta-methylene-ATP; antinociception; beta(2)-adrenoceptor; mu-opioid receptor; intracerebroventricular;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Satoh, M Kyoto Univ, Fac Pharmaceut Sci, Dept Mol Pharmacol, Kyoto 6068501, Japan Kyoto Univ Kyoto Japan 6068501 Pharmacol, Kyoto 6068501, Japan
Citazione:
M. Fukui et al., "Involvement of beta(2)-adrenergic and mu-opioid receptors in antinociception produced by intracerebroventricular administration of alpha,beta-methylene-ATP", JPN J PHARM, 86(4), 2001, pp. 423-428

Abstract

The present study examined what kind of receptors are involved in the antinociception produced by intracerebroventricular (i.c.v.) administration of alpha,beta -methylene-ATP using antagonists at adrenergic, serotonin or opioid receptors. Antinociceptive effect of alpha,beta -methylene-ATP (10 nmol/rat) was significantly attenuated by subcutaneous pretreatment with propranolol and naloxone, but not phentolamine or methysergide, at a dose of 10 mg/kg. I.c.v. pretreatment with propranolol (100 nmol/rat), butoxamine (100 nmol/rat), ICI-118,551 (100 nmol/rat) and naloxone (30 nmol/rat) significantly attenuated the antinociceptive effect of alpha,beta -methylene-ATP. However, i.c.v. pretreatment with atenolol (100 nmol/rat), naltrindole (30 nmol/rat) or nor-binaltorphimine (30 nmol/rat) did not show any significant effects. These results suggest that supraspinal beta (2)-adrenergic and mu -opioid receptors are involved in the antinociceptive effect of i.c.v. administered alpha,beta -methylene-ATP.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 06:44:33