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Titolo:
Formulation and stability testing of photolabile drugs
Autore:
Tonnesen, HH;
Indirizzi:
Univ Oslo, Inst Pharm, N-0316 Oslo, Norway Univ Oslo Oslo Norway N-0316Univ Oslo, Inst Pharm, N-0316 Oslo, Norway
Titolo Testata:
INTERNATIONAL JOURNAL OF PHARMACEUTICS
fascicolo: 1-2, volume: 225, anno: 2001,
pagine: 1 - 14
SICI:
0378-5173(20010828)225:1-2<1:FASTOP>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
BIOLOGICALLY-ACTIVE COMPOUNDS; L-ASCORBIC-ACID; BETA-CYCLODEXTRIN; AQUEOUS-SOLUTION; SOLID-STATE; PHOTOCHEMICAL DECOMPOSITION; COMPLEX-FORMATION; DOSAGE FORMS; PHOTODEGRADATION; PHOTOSTABILITY;
Keywords:
photolabile drugs; formulation; stability testing;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
94
Recensione:
Indirizzi per estratti:
Indirizzo: Tonnesen, HH Univ Oslo, Inst Pharm, POB 1068 Blindern, N-0316 Oslo, NorwayUniv Oslo POB 1068 Blindern Oslo Norway N-0316 Oslo, Norway
Citazione:
H.H. Tonnesen, "Formulation and stability testing of photolabile drugs", INT J PHARM, 225(1-2), 2001, pp. 1-14

Abstract

Exposure of a drug to irradiation can influence the stability of the formulation, leading to changes in the physicochemical properties of the product. The influence of excipients of frequently used stabilizers is often difficult to predict and, therefore, stability testing of the final preparation is important. The selection of a protective packaging must be based on knowledge about the wavelength causing the instability. Details on drug photoreactivity will also be helpful in order to minimize side-effects and/or optimize drug targeting by developing photoresponsive drug delivery systems. This review focuses on practical problems related to formulation and stability testing of photolabile drugs. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 16:03:41