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Titolo:
Skeletal muscle metabolism in overweight and post-overweight women: an isometric exercise study using P-31 magnetic resonance spectroscopy
Autore:
Newcomer, B; Larson-Meyer, DE; Hunter, GR; Weinsier, RL;
Indirizzi:
Univ Alabama, Dept Crit & Diagnost Care, Birmingham, AL 35294 USA Univ Alabama Birmingham AL USA 35294 gnost Care, Birmingham, AL 35294 USA Univ Alabama, Dept Nutr Sci, Div Physiol & Metab, Birmingham, AL 35294 USAUniv Alabama Birmingham AL USA 35294 ol & Metab, Birmingham, AL 35294 USA Univ Alabama, Dept Human Studies, Birmingham, AL 35294 USA Univ Alabama Birmingham AL USA 35294 an Studies, Birmingham, AL 35294 USA
Titolo Testata:
INTERNATIONAL JOURNAL OF OBESITY
fascicolo: 9, volume: 25, anno: 2001,
pagine: 1309 - 1315
SICI:
0307-0565(200109)25:9<1309:SMMIOA>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
MITOCHONDRIAL-FUNCTION; FIBER TYPE; INSULIN-RESISTANCE; PRODUCTION-RATES; ATP PRODUCTION; FORCE-LEVEL; MRS; OBESITY; DETERMINANTS; SENSITIVITY;
Keywords:
overweight; skeletal muscle metabolism; P-31 MRS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Newcomer, B Univ Alabama, Dept Crit & Diagnost Care, 1714 9th Ave S,LRC 374, Birmingham, AL 35294 USA Univ Alabama 1714 9th Ave S,LRC 374 Birmingham AL USA 35294 SA
Citazione:
B. Newcomer et al., "Skeletal muscle metabolism in overweight and post-overweight women: an isometric exercise study using P-31 magnetic resonance spectroscopy", INT J OBES, 25(9), 2001, pp. 1309-1315

Abstract

OBJECTIVE: To investigate whether skeletal muscle anaerobic metabolism, oxidative metabolism or metabolic economy during controlled sub-maximal and near-maximal exercises is altered in overweight women after diet-induced weight reduction, and whether these parameters are different between normal-weight, obesity-prone and normal-weight obesity-resistant women with similar physical fitness levels. DESIGN: A prospective weight loss study of overweight women and their comparison with never overweight controls. SUBJECTS: Thirty overweight, nondiabetic, premenopausal women and 28 neveroverweight controls were included in this analysis. All were participatingin a longitudinal investigation of the role of energy metabolism in the etiology of obesity. The overweight women were recruited specifically to havea positive family history of obesity and have a body mass index (BMI) between 27 and 30 kg/m(2) and were studied in the overweight state and after reduction to a normal weight. The never-overweight controls were recruited specifically to have no personal and family history of obesity and were groupmatched with the weight-reduced post-overweight subjects in terms of premenopausal status, age, BMI, race and sedentary lifestyle. MEASUREMENTS: All testing was performed following one month of weight maintenance and during the follicular phase of the menstrual cycle. Hydrostaticweighing was performed to measure body composition and a whole-body maximal oxygen uptake (VO2max) test was done to measure aerobic fitness. P-31 MRSwas used to determine ATP production from oxidative phosphorylation (OxPhos), 'anaerobic' glycolysis (AnGly), and creatine kinase (CK), as well as muscle metabolic economy. The time constant of ADP (TCADP), V-PCr (ie the initial rate of PCr resynthesis following exercise), and Q(max) (ie the apparent maximal oxidative ATP production rate) were also calculated as additional markers of mitochondrial function. RESULTS: Diet-induced weight loss did not have any effects on the anaerobic metabolism markers (AnGly and CK). The aerobic metabolism markers calculated from the initial recovery data (OxPhos and V-PCr) were unaffected by diet-induced weight loss. However, diet-induced weight loss resulted in improvements in the TCADP and Q(max) in the post-overweight state as compared totheir overweight state. There were no differences in any of the anaerobic (AnGly and CK) or oxidative metabolism markers (OxPhos, V-PCr, Q(max) and TCADP) between the post-overweight and control groups. CONCLUSIONS: Once the overweight women were reduced to a normal-weight state, their skeletal muscle energy metabolism and economy was similar to the never overweight control women. In overweight women, oxidative metabolism or mitochondrial function may be limited by blood flow to the muscle following the cessation of exercise.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 13:13:42