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Titolo:
Expression of apoptosis regulatory proteins in the skeletal muscle of tumor-bearing rabbits compared with diet-restricted rabbits
Autore:
Ishiko, O; Sumi, T; Yoshida, H; Hyun, Y; Ogita, S;
Indirizzi:
Osaka City Univ, Sch Med, Dept Obstet & Gynecol, Abeno Ku, Osaka 5458585, Japan Osaka City Univ Osaka Japan 5458585 ecol, Abeno Ku, Osaka 5458585, Japan
Titolo Testata:
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
fascicolo: 3, volume: 8, anno: 2001,
pagine: 279 - 283
SICI:
1107-3756(200109)8:3<279:EOARPI>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANEMIA-INDUCING SUBSTANCE; PROGRAMMED CELL-DEATH; CYCLIC PLASMA PERFUSION; CANCER CACHEXIA; NECROSIS-FACTOR; BCL-2; DNA;
Keywords:
cachexia; bcl-2; bax; apoptosis; VX2 carcinoma;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Ishiko, O Osaka City Univ, Sch Med, Dept Obstet & Gynecol, Abeno Ku, 1-4-3Asahimachi, Osaka 5458585, Japan Osaka City Univ 1-4-3 Asahimachi Osaka Japan 5458585 585, Japan
Citazione:
O. Ishiko et al., "Expression of apoptosis regulatory proteins in the skeletal muscle of tumor-bearing rabbits compared with diet-restricted rabbits", INT J MOL M, 8(3), 2001, pp. 279-283

Abstract

The mechanism of body weight loss in the tumor-bearing state is still unclear. In this study, we investigated expressions of apoptosis regulatory proteins in the skeletal muscle,of tumor-bearing and diet-restricted rabbits, and tried to evaluate the differences between the two groups. The apoptoticindex (AI) in the tumor-bearing group was 28.1 +/-2.84 on day 10. By day 20, many more apoptotic cells were found (AI: 40.5 +/-3.20), but then after day 20 their numbers gradually decreased (AI: 9.67 +/-2.22 on day 30 and 0.93 +/-0.96 on day 40). By contrast, no apoptotic cells were detected in thediet-restricted group at any of the times examined. Bcl-2 immunoreactivitywas either not detected at all or only weakly observed in both groups. By contrast, Bax expression increased gradually after implantation in the tumor-bearing group. Bax expression in skeletal muscle cell was graded '++' (moderate) 10 days after tumor implantation, and '+++' (high) by day 20, in 2 of the 5 tumor-bearing rabbits. After day 20, however, Bax immunoreactivitydecreased continuously in the tumor-bearing group. By contrast, hardly anyBax-immuno-positive cells were detected in the diet-restricted group. These results suggest that loss of body weight in the tumor-bearing group is different from that in the diet-restricted group, and is related to apoptosisof skeletal muscles.

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Documento generato il 01/04/20 alle ore 11:24:17