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Titolo:
Calcitonin gene-related peptide (CGRP), acting via CGRP type 1 receptors, inhibits potassium-stimulated aldosterone secretion and enhances basal catecholamine secretion from rat adrenal gland
Autore:
Tortorella, C; Macchi, C; Forneris, M; Nussdorfer, GG;
Indirizzi:
Univ Padua, Sect Anat, Dept Human Anat & Physiol, I-35121 Padua, Italy Univ Padua Padua Italy I-35121 uman Anat & Physiol, I-35121 Padua, Italy
Titolo Testata:
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
fascicolo: 3, volume: 8, anno: 2001,
pagine: 261 - 264
SICI:
1107-3756(200109)8:3<261:CGP(AV>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
IN-VITRO; CHROMAFFIN CELLS; ADRENOMEDULLIN;
Keywords:
calcitonin gene-related peptide; aldosterone; catecholamine; adrenal gland;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
13
Recensione:
Indirizzi per estratti:
Indirizzo: Nussdorfer, GG Univ Padua, Sect Anat, Dept Human Anat & Physiol, Via Gabelli 65, I-35121 Padua, Italy Univ Padua Via Gabelli 65 Padua Italy I-35121 Padua, Italy
Citazione:
C. Tortorella et al., "Calcitonin gene-related peptide (CGRP), acting via CGRP type 1 receptors, inhibits potassium-stimulated aldosterone secretion and enhances basal catecholamine secretion from rat adrenal gland", INT J MOL M, 8(3), 2001, pp. 261-264

Abstract

Calcitonin gene-related peptide (CGRP) is a potent hypotensive peptide, that acts via two main subtypes of receptors, named CGRP I and CGRP2. CGRP belongs to a regulatory-peptide family, that includes adrenomedullin (ADM) whose aldosterone antisecretagogue and catecholamine secretagogue actions arewell demonstrated. Quantitative autoradiography showed the presence of [I-125]CGRP binding sites in both rat adrenal zona glomerulosa (ZG) and medulla. Binding was displaced by the CGRP1-receptor antagonist CGRP(8-37), but not by the CGRP2-receptor agonist [cys(Et)(2,7)]-alpha CGRP (CGRP2-A). CGRP concentration-dependently inhibited 10 mM-stimulated (but not basal) aldosterone secretion from dispersed rat ZG cells, and enhanced basal catecholamine secretion from rat adrenomedullary fragments. The responses to the maximal effective concentration of CGRP (10(-8) M) were blocked by 10(-7) M CGRP(8-37). CGRP2-A (10(-7) M) neither altered aldosterone response to 10 mM Knor enhanced basal catecholamine secretion. The conclusion is drawn that CGRP, like ADM, inhibits agonist-stimulated aldosterone secretion and stimulates basal catecholamine release in the rat, exclusively acting via CGRP1 receptors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 10:35:11