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Titolo:
Myelodysplastic syndrome progresses rapidly into erythroleukemia associated with synchronous double cancers of the stomach and the papilla of Vater
Autore:
Takahashi, T; Kazama, Y; Shimizu, H; Yoshimoto, M; Tsujisaki, M; Aoki, S; Imai, K;
Indirizzi:
Tenshi Hosp, Dept Internal Med 2, Higashi Ku, Sapporo, Hokkaido 0650012, Japan Tenshi Hosp Sapporo Hokkaido Japan 0650012 pporo, Hokkaido 0650012, Japan Dohto Hosp, Dept Internal Med, Sapporo, Hokkaido, Japan Dohto Hosp Sapporo Hokkaido Japan Internal Med, Sapporo, Hokkaido, Japan Sapporo Med Univ, Sch Med, Dept Internal Med 1, Sapporo, Hokkaido, Japan Sapporo Med Univ Sapporo Hokkaido Japan Med 1, Sapporo, Hokkaido, Japan
Titolo Testata:
INTERNATIONAL JOURNAL OF HEMATOLOGY
fascicolo: 1, volume: 74, anno: 2001,
pagine: 64 - 69
SICI:
0925-5710(200107)74:1<64:MSPRIE>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
GASTRIC-CANCER; LEUKEMIA;
Keywords:
del(1)(q42); MDS; erythroleukemia; gastric cancer; carcinoma of Vater papilla;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
14
Recensione:
Indirizzi per estratti:
Indirizzo: Takahashi, T Tenshi Hosp, Dept Internal Med 2, Higashi Ku, Kita-12,Higashi-3,31, Sapporo, Hokkaido 0650012, Japan Tenshi Hosp Kita-12,Higashi-3,31 Sapporo Hokkaido Japan 0650012
Citazione:
T. Takahashi et al., "Myelodysplastic syndrome progresses rapidly into erythroleukemia associated with synchronous double cancers of the stomach and the papilla of Vater", INT J HEMAT, 74(1), 2001, pp. 64-69

Abstract

Patients with myelodysplastic syndrome (MDS) show a relatively high incidence of developing cancers. However, it is extremely rare that synchronous double cancers develop in an MDS patient. We report a case of MDS that progressed rapidly into erythroleukemia (M6 by French-American-British classification) complicated by gastric cancer and carcinoma of the papilla of Vater. A 66-year-old man was admitted because of pancytopenia with peripheral blasts. A diagnosis of MDS (with refractory anemia with excess of blasts in transformation [RAEB-T]) was made by bone marrow examination. Chromosome analysis revealed 46,XY. An early gastric cancer was also diagnosed by endoscopic examination. The peripheral blasts gradually proliferated and the disease progressed to M6. A chromosome abnormality 46,XY,del(1)(q42) was detectedat the leukemic transformation. A CAG (low-dose cytarabine and aclarubicinin combination with granulocyte colony-stimulating factor) regimen was started as a remission-induction therapy. However, obstructive jaundice developed and a marked dilatation of bile ducts was observed by abdominal computed tomography (CT). A carcinoma of the papilla of Vater was detected by endoscopy. As remission was achieved and the pancytopenia improved. the patientsubsequently underwent a surgical jejuno-choledochostomy to manage the jaundice. However, the leukemia relapsed thereafter and additional chromosome abnormalities including der(5)t(5;10)(p15;q11) were observed. (C) 2001 The Japanese Society of Hematology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 22:08:07