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Titolo:
Involvement of the NUP98 gene in a chromosomal translocation t(11;20)(p15;q11.2) in a patient with acute monocytic leukemia (FAB-M5b)
Autore:
Kakazu, N; Shinzato, I; Arai, Y; Gotoh, S; Matsushita, A; Ishikawa, T; Nagai, K; Takahashi, T; Ohno, T; Tsuchiya, T; Ohki, M; Abe, T;
Indirizzi:
Kyoto Prefectural Univ Med, Dept Hyg, Kamigyo Ku, Kyoto 6028566, Japan Kyoto Prefectural Univ Med Kyoto Japan 6028566 Ku, Kyoto 6028566, Japan Kobe City Gen Hosp, Dept Hematol & Clin Immunol, Kobe, Hyogo, Japan Kobe City Gen Hosp Kobe Hyogo Japan l & Clin Immunol, Kobe, Hyogo, Japan Natl Canc Ctr, Res Inst, Canc Genom Div, Tokyo 104, Japan Natl Canc Ctr Tokyo Japan 104 Res Inst, Canc Genom Div, Tokyo 104, Japan Ohtsu Red Cross Hosp, Dept Internal Med, Ohtsu, Shiga, Japan Ohtsu Red Cross Hosp Ohtsu Shiga Japan Internal Med, Ohtsu, Shiga, Japan Shionogi Biomed Labs, Tokyo, Japan Shionogi Biomed Labs Tokyo JapanShionogi Biomed Labs, Tokyo, Japan
Titolo Testata:
INTERNATIONAL JOURNAL OF HEMATOLOGY
fascicolo: 1, volume: 74, anno: 2001,
pagine: 53 - 57
SICI:
0925-5710(200107)74:1<53:IOTNGI>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACUTE MYELOGENOUS LEUKEMIA; MYELODYSPLASTIC SYNDROME; MYELOID MALIGNANCIES; NUCLEOPORIN GENE; DE-NOVO; FUSION; T(7-11)(P15-P15); INV(11)(P15Q22); FUSES; HOXA9;
Keywords:
t(11;20)(p15;q11.2); NUP98; fluorescence in situ hybridization;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
11
Recensione:
Indirizzi per estratti:
Indirizzo: Kakazu, N Kyoto Prefectural Univ Med, Dept Hyg, Kamigyo Ku, Kyoto 6028566,Japan Kyoto Prefectural Univ Med Kyoto Japan 6028566 6028566, Japan
Citazione:
N. Kakazu et al., "Involvement of the NUP98 gene in a chromosomal translocation t(11;20)(p15;q11.2) in a patient with acute monocytic leukemia (FAB-M5b)", INT J HEMAT, 74(1), 2001, pp. 53-57

Abstract

We report here a case of acute monocytic leukemia (M5b subtype according to the French-American-British [FAB]classification) with chromosomal translocation t(11;20)(p15;q11.2). Fluorescence in situ hybridization analysis with a probe for the NUP98 gene, which is located at chromosome band 11p15, showed that the probe hybridized to both derivative chromosomes 11 and 20 as well as to the remaining normal chromosome 11, indicating that the NUP98 gene was split and involved in this translocation. This is the first report of t(11;20)(p15;q11.2) involving the NUP98 gene in overt leukemia. (C) 2001 The Japanese Society of Hematology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 12:28:36