Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Methylenedioxymethamphetamine (MDMA; 'Ecstasy') suppresses antigen specific IgG(2a) and IFN-gamma production
Autore:
Connor, TJ; Connelly, DB; Kelly, JP;
Indirizzi:
Natl Univ Ireland Univ Coll Galway, Dept Pharmacol, Galway, Ireland Natl Univ Ireland Univ Coll Galway Galway Ireland acol, Galway, Ireland
Titolo Testata:
IMMUNOLOGY LETTERS
fascicolo: 2, volume: 78, anno: 2001,
pagine: 67 - 73
SICI:
0165-2478(20010903)78:2<67:M('SAS>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
3,4-METHYLENEDIOXYMETHAMPHETAMINE MDMA; IN-VIVO; ANTIBODY; AMPHETAMINE; RATS; MICE;
Keywords:
amphetamine; antibody; humoral immunity; IFN-gamma; IL-6; Ig-G(2a); KLH; MDMA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Connor, TJ Natl Univ Ireland Univ Coll Galway, Dept Pharmacol, Galway, Ireland Natl Univ Ireland Univ Coll Galway Galway Ireland y, Ireland
Citazione:
T.J. Connor et al., "Methylenedioxymethamphetamine (MDMA; 'Ecstasy') suppresses antigen specific IgG(2a) and IFN-gamma production", IMMUNOL LET, 78(2), 2001, pp. 67-73

Abstract

Methylenedioxymethiamphetamine (MDMA; 'Ecstasy') is a widely abused amphetamine derivative. In the present study, we examined the effect of acute MDMA administration on an antigen specific immune response. Responsiveness to an in vivo challenge with the soluble protein antigen keyhole limpet haemocyanin (KLH) was examined in rats following MDMA administration (2.5, 5 or 10 mg/kg; i.p.). KLH-specific serum IgM concentrations were measured 7 days following challenge, and serum IgG concentrations were measured 14 days following the KLH challenge. In addition, antigen-specific IFN-gamma and IL-6 production was measured in kLH-stimulated splenocytes. MDMA did not alter the KLH-specific IgM response. In contrast, MDMA (5 and 10 mg/kg) provoked asignificant suppression of KLH-specific IgG production. Thus, MDMA administration did not alter the initial generation of the antibody response but rather inhibited antibody class switching from IgM to IgG. Two pathways for the genetic switch from IgM to IgG production were investigated. One pathway requires the Th, type cytokine IFN-gamma to stimulate IgM-secreting cellsto switch to IgG(2a)-secreting cells. Another pathway requires the Th-2 type cytokines IL-4 and IL-6 to stimulate IgM-secreting cells to switch to IgG(1)-secreting cells. IgG, and IgG(2a) levels were measured to determine ifthese two pathways were differentially affected. The results indicate thatonly IgG(2a) levels were decreased following MDMA administration. Furthermore, this decrease in IgG, was accompanied by decreased KLH-specific IFN-gamma production 14 days post KLH administration. In conclusion, these data indicate that MDMA alters the ability to switch from IgM to IgG(2a) production, possibly by reducing IFN-gamma. Potential health consequences for MDMA users are discussed. (C) 2001 Elsevier Science BN. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/02/20 alle ore 05:16:00