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Titolo:
Structural organization of the human MS4A gene cluster on Chromosome 11q12
Autore:
Liang, YH; Buckley, TR; Tu, LL; Langdon, SD; Tedder, TF;
Indirizzi:
Duke Univ, Med Ctr, Dept Immunol, Durham, NC 27710 USA Duke Univ Durham NC USA 27710 Med Ctr, Dept Immunol, Durham, NC 27710 USA Duke Univ, Dept Biol, Durham, NC 27710 USA Duke Univ Durham NC USA 27710Duke Univ, Dept Biol, Durham, NC 27710 USA
Titolo Testata:
IMMUNOGENETICS
fascicolo: 5, volume: 53, anno: 2001,
pagine: 357 - 368
SICI:
0093-7711(200107)53:5<357:SOOTHM>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
FC-EPSILON-RI; AFFINITY IGE RECEPTOR; IMMUNOGLOBULIN-E RECEPTOR; CATION CHANNEL CD20; B1 DIFFERENTIATION ANTIGEN; BALB/C 3T3 CELLS; BETA-SUBUNIT; TRANSFECTED CELLS; ATOPIC-DERMATITIS; PROTEIN;
Keywords:
MS4A gene family; CD20; Fc epsilon RI beta; HTm4; gene cluster;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
54
Recensione:
Indirizzi per estratti:
Indirizzo: Tedder, TF Duke Univ, Med Ctr, Dept Immunol, Box 3010,Room 353 Jones Bldg,Res Dr, Durham, NC 27710 USA Duke Univ Box 3010,Room 353 Jones Bldg,Res Dr Durham NC USA 27710
Citazione:
Y.H. Liang et al., "Structural organization of the human MS4A gene cluster on Chromosome 11q12", IMMUNOGENET, 53(5), 2001, pp. 357-368

Abstract

CD20, the high-affinity IgE receptor beta chain (Fc epsilon RI beta), and HTm4 are structurally related cell surface proteins expressed by hematopoietic cells. Recently, 16 novel human and mouse genes were identified that encode new members of this nascent protein family that we have named the membrane-spanning 4A gene family, with at least 12 subgroups (MS4A1-MS4A12). Inthe current study, we identified three additional human MS4A genes: MS4A4E, MS4A6E, and MS4A10. All family members have at least four potential transmembrane domains and N- and C-terminal cytoplasmic domains encoded by distinct exons, except MS4A6E which contains two transmembrane domains. Otherwise, the 12 currently identified MS4A genes share common structural features and similar intron/exon splice boundaries, and are clustered along an similar to 600-kb region of Chromosome 11q12. In contrast to other MS4A genes, MS4A4E, MS4A6E, and MS4A10 transcripts were rare and not detected among hematopoietic cells and most nonlymphoid tissues. Sequence polymorphisms were identified in the MS4A6E gene and common splice variants were observed for the MS4A4A, MS4A5, MS4A6A, and MS4A7 genes. Thus, the MS4A family currently includes 24 distinct human and mouse genes. Like CD20 and Fc epsilon RI beta, the 10 other human MS4A family members are likely to be components of oligomeric cell surface complexes involved in signal transduction in diverse cell lineages.

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Documento generato il 29/03/20 alle ore 15:08:29