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Titolo:
Pinhole SPECT of mice using the LumaGEM gamma camera
Autore:
MacDonald, LR; Patt, BE; Iwanczyk, JS; Tsui, BMW; Wang, YC; Frey, EC; Wessell, DE; Acton, PD; Kung, HF;
Indirizzi:
Photon Imaging Inc, Gamma Medica Instruments Div, Northridge, CA 91324 USAPhoton Imaging Inc Northridge CA USA 91324 Div, Northridge, CA 91324 USA Univ N Carolina, Dept Biomed Engn, Chapel Hill, NC 27599 USA Univ N Carolina Chapel Hill NC USA 27599 Engn, Chapel Hill, NC 27599 USA Univ Penn, Dept Radiol, Philadelphia, PA 19104 USA Univ Penn PhiladelphiaPA USA 19104 pt Radiol, Philadelphia, PA 19104 USA
Titolo Testata:
IEEE TRANSACTIONS ON NUCLEAR SCIENCE
fascicolo: 3, volume: 48, anno: 2001,
parte:, 2
pagine: 830 - 836
SICI:
0018-9499(200106)48:3<830:PSOMUT>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
ULTRA-HIGH-RESOLUTION; RADIOLABELED MONOCLONAL-ANTIBODIES; IN-VIVO; NUCLEAR-MEDICINE; SMALL ANIMALS; RECEPTORS; DETECTOR; THERAPY; SYSTEM;
Keywords:
animal SPECT; high-resolution SPECT; Lumagem; small animal imaging; small gamma camera;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Engineering, Computing & Technology
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: MacDonald, LR Photon Imaging Inc, Gamma Medica Instruments Div, Northridge, CA 91324 USA Photon Imaging Inc Northridge CA USA 91324 ge, CA 91324 USA
Citazione:
L.R. MacDonald et al., "Pinhole SPECT of mice using the LumaGEM gamma camera", IEEE NUCL S, 48(3), 2001, pp. 830-836

Abstract

LumaGEM is a newly developed gamma camera for dedicated, small field of view, high spatial resolution imaging. The system consists of an array of 2 x2 x 6 mm(3) NaI(TI) pixels coupled to an array of position-sensitive photomultiplier tubes. It has a 125 x 125 mm(2) field of view. A pinhole collimator was used on LumaGEM to acquire SPECT images of mice that had transgenicmodifications so as to model various diseases. Pinhole apertures of 1, 2, and 3 nun are interchangeable on the collimator and were used to acquire images. An iterative MLEM algorithm for pinhole SPECT was used to reconstruct the 128 projection images that covered 360 degrees rotation. The reconstructionalgorithm is based on a projector and back projector pair implemented using a ray-tracing algorithm. The crucial reconstruction input parameters are the radius of rotation, center of rotation, and pinhole focal length. Idealpinhole geometry is assumed, and no correction for attenuation has been made. The preliminary images presented here show detailed uptake in the mice subjects and are a convincing sign that animal SPECT can reach submillimeter spatial resolution and be a valuable tool in the study of diseases and the development of pharmaceuticals in animal models.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 15:10:49