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Titolo:
An investigation of coded aperture imaging for small animal SPECT
Autore:
Meikle, SR; Fulton, RR; Eberl, S; Dahlbom, M; Wong, KP; Fulham, MJ;
Indirizzi:
Royal Prince Alfred Hosp, Dept PET & Nucl Med, Sydney, NSW 2050, AustraliaRoyal Prince Alfred Hosp Sydney NSW Australia 2050 y, NSW 2050, Australia Univ Calif Los Angeles, Sch Med, Dept Mol & Med Pharmacol, Los Angeles, CA90021 USA Univ Calif Los Angeles Los Angeles CA USA 90021 Los Angeles, CA90021 USA
Titolo Testata:
IEEE TRANSACTIONS ON NUCLEAR SCIENCE
fascicolo: 3, volume: 48, anno: 2001,
parte:, 2
pagine: 816 - 821
SICI:
0018-9499(200106)48:3<816:AIOCAI>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON-EMISSION-TOMOGRAPHY; RECONSTRUCTION;
Keywords:
animals; coded apertures; image reconstruction; iterative methods; single-photon emission computed tomography; (SPECT);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Engineering, Computing & Technology
Citazioni:
13
Recensione:
Indirizzi per estratti:
Indirizzo: Meikle, SR Royal Prince Alfred Hosp, Dept PET & Nucl Med, Sydney, NSW 2050, Australia Royal Prince Alfred Hosp Sydney NSW Australia 2050 , Australia
Citazione:
S.R. Meikle et al., "An investigation of coded aperture imaging for small animal SPECT", IEEE NUCL S, 48(3), 2001, pp. 816-821

Abstract

Coded apertures provide a substantial gain in detection efficiency compared with conventional collimation and are well suited to imaging small volumes. In this work, we investigated several aspects of coded aperture design for a small animal SPECT system, including aperture/detector configuration, sampling requirements, and susceptibility to scatter. We simulated various source distributions and detection systems which included one, two, and four stationary detectors placed around the object, each with a pinhole array or a Fresnel zone plate in front of the detector. Image volumes were reconstructed using an iterative successive over-relaxation algorithm with a penalized weighted least squares cost function. Multiple pinhole arrays performed better than Fresnel zone plates in terms of reconstructed mean squared error and signal-to-noise. Our design goals of <2 mm spatial resolution (full width at half maximum) and >1% detection efficiency can be achieved with a four-detector system with arrays of 100 pinholes per detector and the scatter fraction for a 2-cm diameter object is <5%. We conclude that a coded aperture design shows great promise for small animal SPECT.

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Documento generato il 22/01/20 alle ore 18:59:47