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Titolo:
High-resolution absolute SPECT quantitation for I-131 distributions used in the treatment of lymphoma: A phantom study
Autore:
Gonzalez, DE; Jaszczak, RJ; Bowsher, JE; Akabani, G; Greer, KL;
Indirizzi:
Duke Univ, Med Ctr, Dept Radiol, Durham, NC 27710 USA Duke Univ Durham NCUSA 27710 Med Ctr, Dept Radiol, Durham, NC 27710 USA Duke Univ, Dept Biomed Engn, Durham, NC 27710 USA Duke Univ Durham NC USA27710 niv, Dept Biomed Engn, Durham, NC 27710 USA Duke Univ, Med Ctr, Dept Radiol, Durham, NC 27710 USA Duke Univ Durham NCUSA 27710 Med Ctr, Dept Radiol, Durham, NC 27710 USA
Titolo Testata:
IEEE TRANSACTIONS ON NUCLEAR SCIENCE
fascicolo: 3, volume: 48, anno: 2001,
parte:, 2
pagine: 707 - 714
SICI:
0018-9499(200106)48:3<707:HASQFI>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
COMPTON-SCATTER CORRECTION; ANTI-B1 RADIOIMMUNOTHERAPY; COMPUTED-TOMOGRAPHY; ANTIBODY THERAPY; EMISSION; RECONSTRUCTION;
Keywords:
biomedical applications of nuclear radiation; biomedical nuclear imaging; image reconstruction; nuclear tomography; single photon emission computed tomography;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Engineering, Computing & Technology
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Gonzalez, DE GE Co, Corp Res & Dev, Niskayuna, NY 12309 USA GE Co Niskayuna NY USA 12309 & Dev, Niskayuna, NY 12309 USA
Citazione:
D.E. Gonzalez et al., "High-resolution absolute SPECT quantitation for I-131 distributions used in the treatment of lymphoma: A phantom study", IEEE NUCL S, 48(3), 2001, pp. 707-714

Abstract

Clinical lymphoma I-131 radioimmunotherapy (RIT) studies are underway at our institution. The effectiveness of treatment can be evaluated through accurate time-dependent three-dimensional (3-D) dosimetry calculations based on SPECT images. We compared the absolute quantitative SPECT performance of a high-resolution rotating parallel-hole collimator (RPHC) designed to minimize septal penetration with that of a traditional medium-energy parallel-hole collimator (MEPHC). We scanned a phantom consisting of four spheres having inner diameters of 2.2 and 2.8 cm and whose activity concentration ratios with respect to the surrounding medium were between 5:1 and 17:1. Imageswere reconstructed using the OSEM algorithm (10 subsets, 20 iterations) with spatial resolution modeling. Quantitation of the MEPHC SPECT images yielded a large overestimation of the surrounding activity concentration (50%) due to septal penetration. Quantitation of the RPHC SPECT image yielded a surrounding medium activity concentration within 8% of the expected value, and the activity within the spheres was estimated to within 20% of their absolute expected values for the RPHC. We also investigated the effect of out of field-of-view (FOV) uncollimated gamma rays on SPECT quantitation. We conclude that for the present quantitation application, the benefits of septal penetration suppression by the RPHC outweigh the increased image noise due to low count rate. These results point to the feasibility of using a large-FOV collimator based on the imaging principles of the RPHC for accurate clinical SPECT quantitation of I-131 RIT.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 15:54:40