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Titolo:
Impaired skin capillary recruitment in essential hypertension is caused byboth functional and structural capillary rarefaction
Autore:
Serne, EH; Gans, ROB; ter Maaten, JC; Tangelder, GJ; Donker, AJM; Stehouwer, CDA;
Indirizzi:
Vrije Univ Amsterdam, Acad Hosp, Dept Med, NL-1007 MB Amsterdam, Netherlands Vrije Univ Amsterdam Amsterdam Netherlands NL-1007 MB erdam, Netherlands Vrije Univ Amsterdam, Dept Physiol, NL-1007 MB Amsterdam, Netherlands Vrije Univ Amsterdam Amsterdam Netherlands NL-1007 MB erdam, Netherlands Vrije Univ Amsterdam, Inst Cardiovasc Res, NL-1007 MB Amsterdam, Netherlands Vrije Univ Amsterdam Amsterdam Netherlands NL-1007 MB erdam, Netherlands Univ Groningen Hosp, Dept Med, Groningen, Netherlands Univ Groningen HospGroningen Netherlands t Med, Groningen, Netherlands
Titolo Testata:
HYPERTENSION
fascicolo: 2, volume: 38, anno: 2001,
pagine: 238 - 242
SICI:
0194-911X(200108)38:2<238:ISCRIE>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
REACTIVE HYPEREMIA; BLOOD-PRESSURE; MICROVASCULAR FUNCTION; BORDERLINE HYPERTENSION; MICROSCOPY; DENSITY; MUSCLE; RATS;
Keywords:
hypertension, essential; microcirculation; capillaries; vascular resistance;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Stehouwer, CDA Vrije Univ Amsterdam, Acad Hosp, Dept Med, Boelelaan 1117, NL-1007 MB Amsterdam, Netherlands Vrije Univ Amsterdam Boelelaan 1117 Amsterdam Netherlands NL-1007 MB
Citazione:
E.H. Serne et al., "Impaired skin capillary recruitment in essential hypertension is caused byboth functional and structural capillary rarefaction", HYPERTENSIO, 38(2), 2001, pp. 238-242

Abstract

Capillary rarefaction occurs in many tissues in patients with essential hypertension and may contribute to an increased vascular resistance and impaired muscle metabolism. Rarefaction may be caused by a structural (anatomic)absence of capillaries, functional nonperfusion, or both. The aim of this study was to assess the extent of structural versus functional capillary rarefaction in the skin of subjects with essential hypertension. We examined skin capillary density with video microscopy before and during maximizationof the number or perfused capillaries by venous congestion (structural capillary number) and before and during postocclusive reactive hyperemia (capillary recruitment, which may have a structural and/or functional basis). The study group was composed or 26 patients with never-treated essential hypertension and 26 normotensive control subjects. In both groups, intermittently perfused capillaries in the resting state were an important functional reserve for recruitment during postocclusive hyperemia. Recruitment of perfused capillaries during postocclusive reactive hyperemia was decreased in the hypertensive subjects compared with normotensive control subjects (47.9 +/-6.8 versus 55.3 +/-8.2 capillaries/mm(2), respectively; P<0.01). During venous occlusion, maximal capillary density was significantly lower in the hypertensive subjects than in the control subjects (52.5<plus/minus>6.6 versus 57.2 +/-8.6 capillaries/mm(2), respectively; P<0.05), suggesting structural rarefaction. However, in the hypertensive subjects compared with the normotensive subjects, a smaller proportion of the maximal number of capillaries was perfused during postocclusive hyperemia (91.6<plus/minus>7.5% versus 97.2 +/-2.7%, respectively; P<0.05), suggesting an additional functional impairment of capillary recruitment. If the difference in capillary numbersduring venous congestion (<approximate to>4.6 capillaries/mm(2)) truly reflects the structural difference between the normotensive and hypertensive subjects, then, at most, 62% (4.6/7.4X100%) of the difference in capillary numbers during postocclusive hyperemia (approximate to7.4 capillaries/mm(2))can be explained by structural defects, and at least 38% can be explained by functional defects. In conclusion, in patients with essential hypertension, recruitment of perfused capillaries is impaired, which can be explainedby both functional and structural rarefaction.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 00:28:46