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Titolo:
Malignant peripheral nerve sheath tumours: high Ki67 labelling index is the significant prognostic indicator
Autore:
Watanabe, T; Oda, Y; Tamiya, S; Kinukawa, N; Masuda, K; Tsuneyoshi, M;
Indirizzi:
Kyushu Univ, Grad Sch Med Sci, Dept Anat Pathol, Higashi Ku, Fukuoka 8128582, Japan Kyushu Univ Fukuoka Japan 8128582 ol, Higashi Ku, Fukuoka 8128582, Japan Kyushu Univ, Grad Sch Med Sci, Dept Med Informat Sci, Fukuoka 8128582, Japan Kyushu Univ Fukuoka Japan 8128582 d Informat Sci, Fukuoka 8128582, Japan Kyushu Univ, Grad Sch Med Sci, Dept Clin Radiol, Fukuoka 8128582, Japan Kyushu Univ Fukuoka Japan 8128582 pt Clin Radiol, Fukuoka 8128582, Japan
Titolo Testata:
HISTOPATHOLOGY
fascicolo: 2, volume: 39, anno: 2001,
pagine: 187 - 197
SICI:
0309-0167(200108)39:2<187:MPNSTH>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
SOFT-TISSUE SARCOMAS; MONOCLONAL-ANTIBODY KI-67; FIXED PARAFFIN SECTIONS; P53 GENE-PRODUCT; CELL-PROLIFERATION; NUCLEAR ANTIGEN; FIBROUS HISTIOCYTOMA; MOLECULAR ABNORMALITIES; MDM2 AMPLIFICATION; SUPPRESSOR GENE;
Keywords:
Ki67; MDM2; MPNST (malignant peripheral nerve sheath tumour); p21(WAF1/CIP1); p53;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Tsuneyoshi, M Kyushu Univ, Grad Sch Med Sci, Dept Anat Pathol, Higashi Ku,3-1-1 Maidashi, Fukuoka 8128582, Japan Kyushu Univ 3-1-1 Maidashi FukuokaJapan 8128582 582, Japan
Citazione:
T. Watanabe et al., "Malignant peripheral nerve sheath tumours: high Ki67 labelling index is the significant prognostic indicator", HISTOPATHOL, 39(2), 2001, pp. 187-197

Abstract

Aims: We investigated p53, Ki67, MDM2, and p21(WAF1/CIP1) in order to evaluate its relationship with prognosis in malignant peripheral nerve sheath tumours (MPNST). Methods and results: In 49 cases of MPNSTs, the immunohistochemical studies of Ki67, p53, MDM2, p21(WAF1/CIP1) and polymerase chain reaction single-strand conformation polymorphism (PCR-SSCP) with direct sequencing of p53 were performed with the formalin-fixed paraffin-embedded tissue. In 43 cases with survival data available, an evaluation of the prognostic significance of clinicopathological factors was also carried out. A high Ki67 labelling index (LI) (>25%) was correlated with a reduced survival rate in the 43 cases of MPNST (P = 0.0106, log-rank test). Furthermore, there was a significant correlation between the Ki67 LI and the immunohistochemical expression of p53 or MDM2. In 17 MPNST cases, PCR amplification of exons 5 through 8 ofthe p53 gene was successful. One case showed a base change of codon 240 (AGT --> AGC), but translated amino acid (Ser) remained unchanged. Multivariate Cox analysis of our series showed that the association of von Recklinghausen's disease, tumour depth, and the presence of rhabdomyoblasts (malignant triton tumour) each had an independent negative impact on overall survival. Conclusion: High Ki67 LI (>25%) was of significant prognostic value in MPNST.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 09:52:00