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Titolo:
Hepatocellular carcinoma: an overview
Autore:
Anthony, PP;
Indirizzi:
Royal Devon & Exeter Healthcare NHS Trust, Dept Histopathol, Exeter, Devon, England Royal Devon & Exeter Healthcare NHS Trust Exeter Devon England , England
Titolo Testata:
HISTOPATHOLOGY
fascicolo: 2, volume: 39, anno: 2001,
pagine: 109 - 118
SICI:
0309-0167(200108)39:2<109:HCAO>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEPATITIS-C VIRUS; LIVER-CELL DYSPLASIA; MAJOR RISK FACTOR; ADENOMATOUS HYPERPLASIA; CIRRHOTIC LIVERS; MACROREGENERATIVE NODULES; ALCOHOL-CONSUMPTION; RISING INCIDENCE; NUCLEAR ANTIGEN; TRANSGENIC MICE;
Keywords:
hepatocellular carcinoma; epidemiology; aetiology; hepatitis B virus; hepatitis C virus; aflatoxin; alcohol; cirrhosis; macroregenerative nodule; adenomatous hyperplasia; dysplasia; hepatocarcinogenesis; tumour regression; molecular biology; immunocytochemistry;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
89
Recensione:
Indirizzi per estratti:
Indirizzo: Anthony, PP Royal Devon & Exeter Hosp, Dept Histopathol, Exeter EX2 5AD, Devon, England Royal Devon & Exeter Hosp Exeter Devon England EX2 5AD ngland
Citazione:
P.P. Anthony, "Hepatocellular carcinoma: an overview", HISTOPATHOL, 39(2), 2001, pp. 109-118

Abstract

Hepatocellular carcinoma remains widely prevalent in tropical Africa and south-east Asia and is largely related to chronic hepatitis B virus (HBV) infection. Primary prevention by vaccination of infants at or near birth is effective but any reduction in tumour incidence cannot be expected for decades to come yet, even in those countries in which the necessary resources exist, as millions of adults remain chronically infected. Meanwhile, the incidence is rising in Japan, Mediterranean countries of Europe, Middle East and North Africa and in the USA, largely due to chronic hepatitis C virus (HCV) infection introduced by the indiscriminate use of unscreened blood and blood products in the recent past. Much has been learned from molecular biological studies on hepatocarcinogenesis incriminating the HBX gene of HBV, the core protein of HCV and a unique guanine to thymine transversion at codon 249 has been observed in cases due to aflatoxin exposure. The subject of precancerous lesions, notably adenomatous/dysplastic nodules and large-cell/small-cell change continues to be a source of much debate and the distinction of nodular lesions in cirrhosis from early carcinoma remains uncertain. Spontaneous regression of hepatocellular carcinoma is rare but it is probably immunologically mediated and treatment by activated T-lymphocytes may reduce recurrence rates after surgery. The positive identification of hepatocellular carcinoma by a liver-specific antibody has greatly facilitated thediagnosis in difficult cases.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 11:44:35