Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Acute stress and dexamethasone rapidly increase hippocampal somatostatin synthesis and release from the dentate gyrus hilus
Autore:
Arancibia, S; Payet, O; Givalois, L; Tapia-Arancibia, L;
Indirizzi:
Univ Montpellier 2, CNRS, UMR 5102, Lab Plast Cerebrale, F-34095 Montpellier, France Univ Montpellier 2 Montpellier France F-34095 -34095 Montpellier, France
Titolo Testata:
HIPPOCAMPUS
fascicolo: 4, volume: 11, anno: 2001,
pagine: 469 - 477
SICI:
1050-9631(2001)11:4<469:ASADRI>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM POTENTIATION; MESSENGER-RNA LEVELS; FREELY MOVING RATS; BRAIN SOMATOSTATIN; IMMOBILIZATION STRESS; POSTSYNAPTIC TARGETS; INSITU HYBRIDIZATION; GABAERGIC NEURONS; PYRAMIDAL NEURONS; APICAL DENDRITES;
Keywords:
rat; hippocampus; in situ hybridization; push-pull perfusion; glucocorticoids;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
71
Recensione:
Indirizzi per estratti:
Indirizzo: Arancibia, S Univ Montpellier 2, CNRS, UMR 5102, Lab Plast Cerebrale, CC090,Pl Eugene Bataillon, F-34095 Montpellier, France Univ Montpellier 2 CC090,Pl Eugene Bataillon Montpellier France F-34095
Citazione:
S. Arancibia et al., "Acute stress and dexamethasone rapidly increase hippocampal somatostatin synthesis and release from the dentate gyrus hilus", HIPPOCAMPUS, 11(4), 2001, pp. 469-477

Abstract

Somatostatin is a neuropeptide whose facilitatory action in the generationof long-term potentiation (LTP) in the hippocampal dentate gyrus has been associated with memory processes. Since stress and memory seem to share some neural pathways, we studied somatostatin release from dentate gyrus hilarcells of the hippocampus in unanesthetized free-moving rats subjected to stress or dexamethasone treatments. In parallel, the number of dentate gyrushilar cells expressing somatostatin mRNA was quantified by nonradioactive in situ hybridization in these two experimental conditions. Rats were stereotaxically implanted with a push-pull cannula in the dentate gyrus hilar region. Animals were perfused 1 week later in basal or stress(30 min immobilization stress) conditions. The other group was intraperitoneally injected with the synthetic glucocorticoid dexamethasone (3 mg/kg b.w.). Samples were collected every 15 min for somatostatin radioimmunoassay. In parallel, in other groups of animals undergoing the same treatments, brains were removed for in situ hybridization studies with an oligonucleotidelabeled with digoxigenin that recognizes somatostatin-14. The results showed that stress induced a significant increase in somatostatin release from dentate gyrus hilar cells 30-45 min after immobilization stress application. Dexamethasone-injected animals exhibited a similar response 45 min after drug administration. In situ hybridization analysis revealed that the two treatments significantly increased the number of cells expressing somatostatin mRNA in the hilar region. In conclusion, somatostatin interneurons of the hippocampal hilar region appear to be a novel stress stimulus target. Their rapid reactivity, expressed as modifications of both somatostatin release and number of cells expressing somatostatin mRNA, provides an interesting model of neuronal plasticity. Hippocampus 2001;11:469-477. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 21:00:57