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Titolo:
Prevention of isolation-induced hypertension by intrahippocampal administration of a nonpeptide kappa-opioid receptor agonist
Autore:
Wright, RC; Ingenito, AJ;
Indirizzi:
E Carolina Univ, Sch Med, Dept Pharmacol, Greenville, NC 27858 USA E Carolina Univ Greenville NC USA 27858 armacol, Greenville, NC 27858 USA
Titolo Testata:
HIPPOCAMPUS
fascicolo: 4, volume: 11, anno: 2001,
pagine: 445 - 451
SICI:
1050-9631(2001)11:4<445:POIHBI>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
SHORT-TERM ISOLATION; BLOOD-BRAIN-BARRIER; ELEVATED PLUS-MAZE; OPIATE RECEPTORS; HEART-RATE; HIPPOCAMPUS; EXPRESSION; PRESSURE;
Keywords:
social isolation; hypertension; kappa-opioid receptor; hippocampus; blood pressure;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Ingenito, AJ E Carolina Univ, Sch Med, Dept Pharmacol, Greenville, NC 27858 USA E Carolina Univ Greenville NC USA 27858 nville, NC 27858 USA
Citazione:
R.C. Wright e A.J. Ingenito, "Prevention of isolation-induced hypertension by intrahippocampal administration of a nonpeptide kappa-opioid receptor agonist", HIPPOCAMPUS, 11(4), 2001, pp. 445-451

Abstract

Previous research in this laboratory showed that hypertension in the spontaneous hypertensive rat (SHR) appears to correlate to insufficient production of hippocampal dynorphins, and that blood pressure could be reduced by intrahippocampal administration of dynorphins and nonpeptide kappa agonists. The purpose of the present study was to investigate whether kappa agonistscould prevent the development of hypertension in a different hypertensive model, i.e., the isolated male rat model of hypertension (IHR). Isolation of young male rats for 5-7 days in standard rat cages caused an increase in systolic blood pressure from a mean of 132 to 184 mmHg. The blood pressures of rats grouped 3 per cage remained stable. Rats received the nonpeptide kappa agonist U62, 066E, (Spiradoline, Upjohn), 10 nmoles/0.2 mul or drug vehicle bilaterally into the the hippocampus for 3 days prior to and during isolation or grouping. Animals treated with U62, 066E did not develop hypertension as compared to isolated animals treated with vehicle. The isolation procedure used in these studies appears to induce anxietal stress, as indicated by reduced time spent by the rats in the open arms of the elevated-plus maze. This time is increased by U62, 066E, suggesting that the drug possesses anxiolytic properties and may reduce hypertension in part,by blocking an anxiety/stress component. These data strengthen our previous findings that opioids in the hippocampus may be important in restraining increased blood pressure provoked by environmental stimuli such as isolation. Hippocampus 2001; 11:445-451. (C) 2001Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 18:29:28