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Titolo:
Cholinergic modulation of pavlovian fear conditioning: Effects of intrahippocampal scopolamine infusion
Autore:
Gale, GD; Anagnostaras, SG; Fanselow, MS;
Indirizzi:
Univ Calif Los Angeles, Dept Psychol & Brain Res Inst, Los Angeles, CA 90095 USA Univ Calif Los Angeles Los Angeles CA USA 90095 Los Angeles, CA 90095 USA
Titolo Testata:
HIPPOCAMPUS
fascicolo: 4, volume: 11, anno: 2001,
pagine: 371 - 376
SICI:
1050-9631(2001)11:4<371:CMOPFC>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONTEXTUAL FEAR; LONG-TERM; DEFENSIVE REACTIONS; RETROGRADE-AMNESIA; HIPPOCAMPAL DAMAGE; DORSAL HIPPOCAMPUS; RAT HIPPOCAMPUS; LESIONS; AMYGDALA; HYPOTHALAMUS;
Keywords:
muscarinic; hippocampus; acquisition; freezing;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Gale, GD Univ Calif Los Angeles, Dept Psychol & Brain Res Inst, Los Angeles, CA 90095 USA Univ Calif Los Angeles Los Angeles CA USA 90095 es, CA 90095 USA
Citazione:
G.D. Gale et al., "Cholinergic modulation of pavlovian fear conditioning: Effects of intrahippocampal scopolamine infusion", HIPPOCAMPUS, 11(4), 2001, pp. 371-376

Abstract

Cholinergic neurotransmission has been implicated in the acquisition of a variety of tasks, including Pavlovian fear conditioning. To more precisely define the role of cholinergic modulation in this process, the effect of site-specific cholinergic antagonism was assessed. Male Long-Evans rats were implanted with chronic, bilateral cannulae aimed at the dorsal hippocampus. Infusions of scopolamine hydrobromide (50 mug bilaterally) or phosphate-buffered saline (PBS) were made immediately prior to a signaled Pavlovian fear conditioning procedure. On consecutive days following training, all rats were given independent tests assessing freezing to both the training context and the tone conditional stimulus (CS). Relative to PBS infused controls,rats that received intrahippocampal infusions of scopolamine showed a significant attenuation of contextual freezing but comparable levels of freezing to the tone CS. Neither shock sensitivity nor general activity levels differed between rats infused with scopolamine or PBS. These findings suggest that fear conditioning to context, but not discrete CS, requires intact cholinergic neurotransmission in the hippocampus. Hippocampus 2001;11:371-376. (C) 2001 Wiley-Liss, Inc.

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Documento generato il 19/01/20 alle ore 14:39:26