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Titolo:
Aminoglycoside ototoxicity in adult CBA, C57BL and BALB mice and the Sprague-Dawley rat
Autore:
Wu, WJ; Sha, SH; McLaren, JD; Kawamoto, K; Raphael, Y; Schacht, J;
Indirizzi:
Univ Michigan, Dept Otolaryngol, Kresge Hearing Res Inst, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 ng Res Inst, Ann Arbor, MI 48109 USA China Cent So Univ, Xiangya Med Sch, Dept Otolaryngol, Changsha, Peoples RChina China Cent So Univ Changsha Peoples R China l, Changsha, Peoples RChina Kansai Med Univ, Dept Otolaryngol, Osaka, Japan Kansai Med Univ Osaka Japan ai Med Univ, Dept Otolaryngol, Osaka, Japan
Titolo Testata:
HEARING RESEARCH
fascicolo: 1-2, volume: 158, anno: 2001,
pagine: 165 - 178
SICI:
0378-5955(200108)158:1-2<165:AOIACC>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED HEARING-LOSS; PRODUCT OTOACOUSTIC EMISSIONS; FREE-RADICAL FORMATION; PIG IN-VIVO; GENTAMICIN OTOTOXICITY; GUINEA-PIG; IRON CHELATORS; F1-HYBRID STRAINS; SENSITIVE PERIOD; MOUSE;
Keywords:
gentamicin; kanamycin; 2,3-dihydroxybenzoate; protection; pigmentation; reactive oxygen species;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Schacht, J Univ Michigan, Dept Otolaryngol, Kresge Hearing Res Inst, 1301 E Ann St, Ann Arbor, MI 48109 USA Univ Michigan 1301 E Ann St Ann Arbor MI USA 48109 MI 48109 USA
Citazione:
W.J. Wu et al., "Aminoglycoside ototoxicity in adult CBA, C57BL and BALB mice and the Sprague-Dawley rat", HEARING RES, 158(1-2), 2001, pp. 165-178

Abstract

The availability of genetic information, transgenic and knock-out animals make the mouse a primary model in biomedical research. Aminoglycoside ototoxicity, however, has rarely been studied in mature mice because they are considered highly resistant to the drugs. This study presents models for kanamycin ototoxicity in adult CBA/J, C57BL/6 and BALB/c mouse strains and a comparison to Sprague-Dawley rats. Five-week-old mice were injected subcutaneously twice daily with 400-900 mg kanamycin base/ kg body weight for 15 days. Kanamycin induced dose-dependent auditory threshold shifts of up to 70 dB at 24 kHz as measured by auditory brain stem-evoked responses. Vestibularfunction was also affected in all strains. The functional deficits were accompanied by hair cell loss in both cochlear and vestibular neurosensory epithelia. Concomitant administration of the antioxidant 2,3-dihydroxybenzoate significantly attenuated the kanamycin-induced threshold shifts. In adultmale Sprague-Dawley rats, doses of 1 X 500 mg or 2 X 300 mg kanamycin base/kg body weight/day X 14 days induced threshold shifts of approximately 50 dB at 20 kHz. These were accompanied by loss of outer hair cells. The orderof susceptibility, BALB > CBA > C57, was not due to differences in the pharmacokinetics of kanamycin. It also did not correlate with the presence of AhllAhl2 genes which predispose C57 and BALB strains, respectively, to accelerated age-related hearing loss. Pigmentation, however, paralleled this rank order suggesting an influence of melanin on cochlear antioxidant status. (C) 2001 Published by Elsevier Science B.V.

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Documento generato il 04/04/20 alle ore 02:21:56