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Titolo:
The total number of neurons and calcium binding protein positive neurons during aging in the cochlear nucleus of CBA/CaJ mice: a quantitative study
Autore:
Idrizbegovic, E; Canlon, B; Bross, LS; Willott, JF; Bogdanovic, N;
Indirizzi:
Huddinge Univ Hosp, Dept Audiol, S-14186 Huddinge, Sweden Huddinge Univ Hosp Huddinge Sweden S-14186 iol, S-14186 Huddinge, Sweden Karolinska Inst, Dept Physiol & Pharmacol, Stockholm, Sweden Karolinska Inst Stockholm Sweden Physiol & Pharmacol, Stockholm, Sweden No Illinois Univ, Dept Psychol, De Kalb, IL 60115 USA No Illinois Univ DeKalb IL USA 60115 Dept Psychol, De Kalb, IL 60115 USA Karolinska Inst, NEUROTEC, Geriatr Sect, Stockholm, Sweden Karolinska Inst Stockholm Sweden ROTEC, Geriatr Sect, Stockholm, Sweden
Titolo Testata:
HEARING RESEARCH
fascicolo: 1-2, volume: 158, anno: 2001,
pagine: 102 - 115
SICI:
0378-5955(200108)158:1-2<102:TTNONA>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
AUDITORY BRAIN-STEM; ELECTRON-MICROSCOPIC IMMUNOCYTOCHEMISTRY; RAT HIPPOCAMPUS; CALBINDIN D-28K; MESSENGER-RNA; GUINEA-PIG; INFERIOR COLLICULUS; CEREBELLAR CORTEX; SENSORY NEURONS; ZEBRA FINCH;
Keywords:
auditory; calbindin; parvalbumin; calretinin; stereology; optical fractionator;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
72
Recensione:
Indirizzi per estratti:
Indirizzo: Idrizbegovic, E Huddinge Univ Hosp, Dept Audiol, S-14186 Huddinge, Sweden Huddinge Univ Hosp Huddinge Sweden S-14186 dinge, Sweden
Citazione:
E. Idrizbegovic et al., "The total number of neurons and calcium binding protein positive neurons during aging in the cochlear nucleus of CBA/CaJ mice: a quantitative study", HEARING RES, 158(1-2), 2001, pp. 102-115

Abstract

The quantitative stereological method, the optical fractionator, was used for determining the total number of neurons and the total number of neuronsimmunostained with parvalbumin, calbindin-D28k (calbindin), and calretininin the dorsal and posteroventral cochlear nucleus (DCN and PVCN) in CBA/CaJ (CBA) mice during aging (1-39 months old). CBA mice have only a modest sensorineural pathology late in life. An age-related decrease of the total number of neurons was demonstrated in the DCN (r = -0.54, P < 0.03), while the total number of neurons in the PVCN did not show any significant age-related differences (r = 0.16, P = 0.57). In the DCN 5.5% of neurons were parvalbumin positive in the very old (30 39 months) mice, vs. 2.2% in the 1 month old mice. In the DCN 3% of the neurons were calbindin immunopositive in the 30-39 months mice compared to 1.9% in the I month old group. In the PVCN. 20% of the neurons in the very old mice were parvalbumin immunopositive. compared to 12% in the young mice. Calbindin did not show any significant age-related differences in the PVCN. The total number of calretinin immunopositive neurons both in the DCN and PVCN did not show any significant changewith increasing age. In conclusion. the total neuronal number in the DCN and PVCN was age-related and region-specific. While the neuronal number in the DCN and PVCN was decreased or unchanged, respectively, the calcium binding protein positive neuronal number showed a graded increase during aging in a region-specific and protein-specific manner. (C) 2001 Published by Elsevier Science B.V.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 01:33:34