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Titolo:
Characterization of the EphA1 receptor tyrosine kinase: Expression in epithelial tissues
Autore:
Coulthard, MG; Lickliter, JD; Subanesan, N; Chen, K; Webb, GC; Lowry, AJ; Koblar, S; Bottema, CDK; Boyd, AW;
Indirizzi:
Royal Brisbane Hosp, Leukaemia Fdn Lab, Queensland Inst Med Res, Brisbane,Qld 4029, Australia Royal Brisbane Hosp Brisbane Qld Australia 4029 sbane,Qld 4029, Australia Univ Queensland, Dept Med, PO Royal Brisbane Hosp, Brisbane, Qld 4029, Australia Univ Queensland Brisbane Qld Australia 4029 Brisbane, Qld 4029, Australia Walter & Eliza Hall Inst Med Res, Parkville, Vic 3050, Australia Walter & Eliza Hall Inst Med Res Parkville Vic Australia 3050 , Australia Univ Adelaide, Waite Agr Res Inst, Glen Osmond, SA 5064, Australia Univ Adelaide Glen Osmond SA Australia 5064 en Osmond, SA 5064, Australia
Titolo Testata:
GROWTH FACTORS
fascicolo: 4, volume: 18, anno: 2001,
pagine: 303 -
SICI:
0897-7194(2001)18:4<303:COTERT>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
LIGAND-BINDING; CELL-LINES; AUTOPHOSPHORYLATION SITE; MELANOMA PROGRESSION; CRYSTAL-STRUCTURE; UP-REGULATION; GENE; FAMILY; DOMAIN; EPHRINS;
Keywords:
Eph; receptor tyrosine kinase; epithelial tissue; genomic organisation; thymus;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
66
Recensione:
Indirizzi per estratti:
Indirizzo: Boyd, AW Royal Brisbane Hosp, Leukaemia Fdn Lab, Queensland Inst Med Res, Brisbane,Qld 4029, Australia Royal Brisbane Hosp Brisbane Qld Australia 4029 4029, Australia
Citazione:
M.G. Coulthard et al., "Characterization of the EphA1 receptor tyrosine kinase: Expression in epithelial tissues", GROW FACTOR, 18(4), 2001, pp. 303

Abstract

The Eph family (of receptor tyrosine kinases plays a crucial role during development and is implicated in oncogenesis. Using a partial cDNA clone of an Eph-related kinase (Esk) we isolated the complete coding region of a gene which we show to be murine EphA1 by both structural and functional criteria. The chromosomal localization is shown to be syntenic to hEphA1 and the genomic organization also shows distinct features found in the hEphA1 gene. Functionally, in keeping with findings for the human homologue, both soluble recombinant and "native" mEphA1 show preferential binding to ephrin A1. However, we also observed significant binding to other A-type ligands as has been observed for other Eph receptors. We analysed the expression of mEphA1 mRNA by in situ hybridization on tissue sections. mEphA1 was expressed in epithelial elements of skin, adult thymus, kidney and adrenal cortex. Taken together with previous Northern blotting data these results suggest thatmEphA1 is expressed widely in differentiated epithelial cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/04/20 alle ore 00:01:23