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Titolo:
Contributions of tissues to expression of a major gene for growth in chimeric mice
Autore:
Calvert, CC; Famula, TR; Anderson, GB;
Indirizzi:
Univ Calif Davis, Dept Anim Sci, Davis, CA 95616 USA Univ Calif Davis Davis CA USA 95616 s, Dept Anim Sci, Davis, CA 95616 USA
Titolo Testata:
GROWTH DEVELOPMENT AND AGING
fascicolo: 1, volume: 65, anno: 2001,
pagine: 15 - 25
SICI:
1041-1232(200121)65:1<15:COTTEO>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAPID POSTWEANING GROWTH; WEIGHT-GAIN; HG; DELETION; LOCUS; MOUSE;
Keywords:
mice; chimera; growth; major gene;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Calvert, CC Univ Calif Davis, Dept Anim Sci, Davis, CA 95616 USA Univ Calif Davis Davis CA USA 95616 Sci, Davis, CA 95616 USA
Citazione:
C.C. Calvert et al., "Contributions of tissues to expression of a major gene for growth in chimeric mice", GROW DEV AG, 65(1), 2001, pp. 15-25

Abstract

The objective of this research was to determine the effect of genotype of particular tissues and organs on the growth of a chimera produced by aggregating an embryo homozygous for the high-growth (hg) allele with an embryo from a control line of wild-type mice lacking the deletion responsible for the high-growth phenotype. A total of 107 chimeric mice were produced, 81 males and 26 females. The preponderance of male chimeras closely fit the expected 3:1 ratio of males to females in balanced chimeric populations, suggesting that neither of the two genetic lines appeared to have a selective advantage for contributions to chimeric tissues. No single correlation betweenindividual tissue chimerism and mouse growth was remarkable relative to correlations of chimerism of other tissues to growth. Other statistical models, including multiple regression techniques, did nothing to identify particular organs, tissues or various combinations that improved the explanation of expression of the high-growth phenotype by percentage of high-growth cells in that organ. These observations suggest that the chromosomal deletion thought to cause the high-growth phenotype has a systemic effect, without dominant effects of or on individual organs or tissues; the precise mechanism has yet to be determined.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/01/20 alle ore 12:58:50