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Titolo:
Interactions between cadmium and zinc in the organism
Autore:
Brzoska, MM; Moniuszko-Jakoniuk, J;
Indirizzi:
Med Acad, Dept Toxicol, PL-15222 Bialystok, Poland Med Acad Bialystok Poland PL-15222 t Toxicol, PL-15222 Bialystok, Poland
Titolo Testata:
FOOD AND CHEMICAL TOXICOLOGY
fascicolo: 10, volume: 39, anno: 2001,
pagine: 967 - 980
SICI:
0278-6915(200110)39:10<967:IBCAZI>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
WISTAR CRL-(WI)BR RATS; DOSE-RESPONSE ANALYSIS; DIETARY ZINC; ORAL CADMIUM; ENVIRONMENTAL EXPOSURE; METAL-IONS; METALLOTHIONEIN SYNTHESIS; INDUCED NEPHROTOXICITY; RENAL METALLOTHIONEIN; INDUCED TOLERANCE;
Keywords:
cadmium; zinc; interactions; toxicity; supplementation; protection;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
135
Recensione:
Indirizzi per estratti:
Indirizzo: Brzoska, MM Med Acad, Dept Toxicol, Mickiewieza 2E Str, PL-15222 Bialystok, Poland Med Acad Mickiewieza 2E Str Bialystok Poland PL-15222 Poland
Citazione:
M.M. Brzoska e J. Moniuszko-Jakoniuk, "Interactions between cadmium and zinc in the organism", FOOD CHEM T, 39(10), 2001, pp. 967-980

Abstract

It is well known that many toxic effects of cadmium (Cd) action result from interactions with essential elements, including zinc (Zn). These interactions can take place at different stages of absorption, distribution in the organism and excretion of both metals and at the stage of Zn biological functions. Exposure to Cd leads to disturbance in Zn in the organism on the one hand, while dietary Zn intake has an important effect on Cd absorption, accumulation and toxicity on the other. The Zn status of the body is important in relation to development cf Cd toxicity. Numerous data show that increased Zn supply may reduce Cd absorption and accumulation and prevent or reduce the adverse actions of Cd, whereas Zn deficiency can intensify Cd accumulation and toxicity. In this review, the interactions between these two trace elements in humans and animals are discussed on the basis of the available literature and our own results, against the background of general population exposure to Cd and common nutritional deficiency of Zn. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/01/20 alle ore 12:26:45