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Titolo:
Effect of sildenafil on ocular haemodynamics
Autore:
Dundar, SO; Dundar, M; Kocak, I; Dayanir, Y; Ozkan, SB;
Indirizzi:
Adnan Menderes Univ, Tip Fak, Dept Ophthalmol, Goz Hastaliklari AD, TR-09100 Aydin, Turkey Adnan Menderes Univ Aydin Turkey TR-09100 ari AD, TR-09100 Aydin, Turkey Adnan Menderes Univ, Dept Urol, Aydin, Turkey Adnan Menderes Univ Aydin Turkey enderes Univ, Dept Urol, Aydin, Turkey Adnan Menderes Univ, Dept Radiol, Aydin, Turkey Adnan Menderes Univ Aydin Turkey deres Univ, Dept Radiol, Aydin, Turkey
Titolo Testata:
EYE
, volume: 15, anno: 2001,
parte:, 4
pagine: 507 - 510
SICI:
0950-222X(200108)15:<507:EOSOOH>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
BLOOD-FLOW VELOCITY; NITRIC-OXIDE; ERECTILE DYSFUNCTION; DOPPLER ULTRASONOGRAPHY; ORAL SILDENAFIL; CYCLIC-GMP; IN-VITRO; ORBIT; ARTERY; RAT;
Keywords:
central retinal artery; colour Doppler ultrasound; ophthalmic artery; sildenafil;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Dundar, SO Adnan Menderes Univ, Tip Fak, Dept Ophthalmol, Goz HastaliklariAD, TR-09100 Aydin, Turkey Adnan Menderes Univ Aydin Turkey TR-09100 09100 Aydin, Turkey
Citazione:
S.O. Dundar et al., "Effect of sildenafil on ocular haemodynamics", EYE, 15, 2001, pp. 507-510

Abstract

Purpose To study the effect of sildenafil, which is an effective agent forthe treatment of erectile dysfunction, on ocular haemodynamics. Methods In this prospective study we examined the effect of a single oral dose of 50 mg sildenafil (Viagra) in a group of healthy young male volunteers, by using colour Doppler ultrasound imaging to measure haemodynamic variables in the central retinal artery (CRA), short temporal posterior ciliaryartery (STPCA) and ophthalmic artery (OA). The following examinations wereperformed on both eyes immediately before and 1 h after a single oral doseof 50 mg sildenafil: visual acuity, intraocular pressure (IOP), colour vision, anterior segment, fundus appearance, resting heart rate, blood pressure and colour Doppler measurements. Results After sildenafil administration, peak systolic velocity, mean velocity and end-diastolic velocity significantly increased in the OA of both eyes. All Dopper indices remained non-significant for the CRA and STPCA of both eyes. Sildenafil did not cause any significant change in IOP, colour vision, visual acuity, systolic blood pressure or diastolic blood pressure. However, heart rate measurements increased significantly after sildenafil administration compared with baseline (p = 0.003). Conclusion The increased flow velocity in the ophthalmic artery seems to be due to a vasodilator effect of sildenafil.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/06/20 alle ore 07:39:30