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Titolo:
The neurokinin-1 receptor antagonist RP 67580 reduces the sensitization ofprimary afferents by substance P in the rat
Autore:
Pawlak, M; Schmidt, RF; Heppelmann, B; Hanesch, U;
Indirizzi:
Univ Wurzburg, Inst Physiol, D-97070 Wurzburg, Germany Univ Wurzburg Wurzburg Germany D-97070 hysiol, D-97070 Wurzburg, Germany
Titolo Testata:
EUROPEAN JOURNAL OF PAIN-LONDON
fascicolo: 1, volume: 5, anno: 2001,
pagine: 69 - 79
SICI:
1090-3801(2001)5:1<69:TNRAR6>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEUROGENIC PLASMA EXTRAVASATION; ROOT GANGLION-CELLS; KNEE-JOINT; TACHYKININ NK1; MESSENGER-RNA; INFLAMMATORY HYPERALGESIA; UNILATERAL INFLAMMATION; SYNOVIAL-FLUID; FLEXOR REFLEX; ANKLE JOINT;
Keywords:
substance P; neurokinin 1; RP 67580;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Pawlak, M Univ Wurzburg, Inst Physiol, Rontgenring 9, D-97070 Wurzburg, Germany Univ Wurzburg Rontgenring 9 Wurzburg Germany D-97070 g, Germany
Citazione:
M. Pawlak et al., "The neurokinin-1 receptor antagonist RP 67580 reduces the sensitization ofprimary afferents by substance P in the rat", EUR J P-LON, 5(1), 2001, pp. 69-79

Abstract

The inflammatory mediator substance P (SP) produces a variety of biological effects in several tissues by binding to the tachyldnin receptor neurokinin 1 (NK1) and, to a lesser extent, by binding to the neurokinin 2 receptor(NK2). To assess the sensitizing effect of SP on articular afferent fibresthe NK1 receptor antagonist RP 67580 was applied in normal and acutely inflamed rat knee joints. Altogether 38 fine afferent nerve Fibres from the rat knee with conductionvelocities of 0.71-13.5 m/s were recorded as single units, during non-noxious and noxious joint rotations. SP, injected i.a. as a bolus close to the knee joint, was able to sensitize 45.5% (10 of 22) of the units recorded from normal joints and 33.3% (five of 15) of afferents from inflamed joints. The following i.a. application of RP 67580 in a range of 20 200 nmol antagonized in a dose-dependent manner the sensitizing effect of SP in a large proportion of slowly conducting articular afferents from normal (66.7%) and inflamed (46.2%) knee joints. Subsequent SP application enhanced the afferent sensitivity further. The electrophysiological results presented here further support the suggestion that the sensitization of afferents by SP in therat knee joint is mediated mainly by the NK, receptor, which is probably located on the primary afferents. (C) 2001 European Federation of Chapters of the International Association for the Study of Pain.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/06/20 alle ore 02:27:48