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Titolo:
Systemic adenosine infusion reduces the area of tactile allodynia in neuropathic pain following peripheral nerve injury: a multi-centre, placebo-controlled study
Autore:
Sjolund, KF; Belfrage, M; Karlsten, R; Segerdahl, M; Arner, S; Gordh, T; Sollevi, A;
Indirizzi:
St Gorans Univ Hosp, Dept Anesthesiol & Intens Care, S-11281 Stockholm, Sweden St Gorans Univ Hosp Stockholm Sweden S-11281 , S-11281 Stockholm, Sweden Karolinska Inst, Karolinska Hosp, Dept Anesthesiol, S-17176 Stockholm, Sweden Karolinska Inst Stockholm Sweden S-17176 siol, S-17176 Stockholm, Sweden Karolinska Inst, Karolinska Hosp, Dept Intens Care, S-17176 Stockholm, Sweden Karolinska Inst Stockholm Sweden S-17176 Care, S-17176 Stockholm, Sweden Univ Uppsala Hosp, S-75185 Uppsala, Sweden Univ Uppsala Hosp Uppsala Sweden S-75185 a Hosp, S-75185 Uppsala, Sweden Huddinge Hosp, S-14186 Huddinge, Sweden Huddinge Hosp Huddinge Sweden S-14186 nge Hosp, S-14186 Huddinge, Sweden
Titolo Testata:
EUROPEAN JOURNAL OF PAIN-LONDON
fascicolo: 2, volume: 5, anno: 2001,
pagine: 199 - 207
SICI:
1090-3801(2001)5:2<199:SAIRTA>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
R-PHENYLISOPROPYL-ADENOSINE; SPINAL DORSAL HORN; MECHANICAL HYPERALGESIA; INTRATHECAL ADENOSINE; SYNAPTIC TRANSMISSION; RECEPTOR; RAT; PHARMACOLOGY; MONONEUROPATHY; SENSITIZATION;
Keywords:
allodynia; hyperalgesia; neuropathy; pain; placebo response; sensory tests;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Belfrage, M St Gorans Univ Hosp, Dept Anesthesiol & Intens Care, S-11281 Stockholm, Sweden St Gorans Univ Hosp Stockholm Sweden S-11281 ockholm, Sweden
Citazione:
K.F. Sjolund et al., "Systemic adenosine infusion reduces the area of tactile allodynia in neuropathic pain following peripheral nerve injury: a multi-centre, placebo-controlled study", EUR J P-LON, 5(2), 2001, pp. 199-207

Abstract

Systemic adenosine has been shown in earlier case reports and a small placebo-con trolled study to reduce pathological sensory dysfunction such as tactile allodynia in neuropathic pain. To evaluate this further, the effects of systemic adenosine infusion (50 mug/kg/min for 60 min) on tactile sensory dysfunction and pain was evaluated in 26 patients suffering peripheral neuropathic pain characterized by dynamic tactile allodynia. A randomized, cross-over, double-blind, placebo-controlled technique was used in this multi-centre study. Psychophysical methods were used to evaluate sensory dysfunction and spontaneous pain. The area of dynamic tactile allodynia was significantly reduced by adenosine compared with placebo (p = 0.043), but spontaneous pain and tactile pain threshold were not significantly improved compared with the effects of placebo treatment. As a secondary outcome, a higher incidence of positive subjective effects on the clinical pain condition, ina few cases with long duration (several months), following adenosine treatment was found when the global effect of respective treatment was assessed (p = 0.028). The results demonstrate involvement of adenosine receptor-sensitive pain mechanisms in some aspects of the sensory dysfunction often found in neuropathic pain. (C) 2001 European Federation of chapters of the International Association for the Study of Pain.

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Documento generato il 02/04/20 alle ore 00:09:29