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Titolo:
Transplant tolerance modifying antibody, to CD200 receptor, but not CD200,alters cytokine production profile from stimulated macrophages
Autore:
Gorczynski, RM;
Indirizzi:
Univ Toronto, Toronto Hosp, Hlth Network, Toronto, ON M5G 2C4, Canada UnivToronto Toronto ON Canada M5G 2C4 twork, Toronto, ON M5G 2C4, Canada Univ Toronto, Dept Surg, Toronto, ON, Canada Univ Toronto Toronto ON Canada v Toronto, Dept Surg, Toronto, ON, Canada Univ Toronto, Dept Immunol, Toronto, ON, Canada Univ Toronto Toronto ON Canada oronto, Dept Immunol, Toronto, ON, Canada
Titolo Testata:
EUROPEAN JOURNAL OF IMMUNOLOGY
fascicolo: 8, volume: 31, anno: 2001,
pagine: 2331 - 2337
SICI:
0014-2980(200108)31:8<2331:TTMATC>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
PORTAL VENOUS IMMUNIZATION; RENAL-ALLOGRAFT SURVIVAL; IN-VIVO; VEIN IMMUNIZATION; DENDRITIC CELLS; MOLECULE OX-2; RAT OX-2; T-CELLS; EXPRESSION; B7-1;
Keywords:
transplantation; tolerance; immunoregulation; costimulation; CD200;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Gorczynski, RM Univ Toronto, Toronto Hosp, Hlth Network, CCRW 2-855,200 Elizabeth St, Toronto, ON M5G 2C4, Canada Univ Toronto CCRW 2-855,200 Elizabeth St Toronto ON Canada M5G 2C4
Citazione:
R.M. Gorczynski, "Transplant tolerance modifying antibody, to CD200 receptor, but not CD200,alters cytokine production profile from stimulated macrophages", EUR J IMMUN, 31(8), 2001, pp. 2331-2337

Abstract

Increased C57BL/6 allograft survival following donor-specific dendritic cell (DC) portal vein (pv) pre-transplant immunization of C3H mice is associated with increased expression of the molecule CD200 on DC, delivery of suppressive signals by CD200(r+), macrophages, and polarization in cytokine production towards type-2 cytokines. Infusion of anti-mouse CD200 monoclonal antibody abolishes these effects. We have used whole Ig, and F(ab')(2) fragments, of anti-CD200 and anti-CD200(r) mAb to explore the relative signalingrole of CD200(+) versus CD200(r+) cells in suppression of type-1 cytokine production in mixed leukocyte cultures (MLC), and enhanced graft survival in vivo. Simple neutralization of CD200 [even by F(ab')(2) antibody] reversed CD200-mediated suppression. However, only whole anti-CD200(r) antibody was effective in stimulating suppression from CD200(r+) cells. Suppression ofcytokine induction following cross-linking of CD200(r+) cells, in vitro was attenuated by anti-IL-6 mAb. Our data are consistent with the hypothesis that CD200(r) itself delivers the crucial intracellular signal leading to immunosuppression, a feature likely of importance in autoimmunity and transplantation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/07/20 alle ore 08:58:59