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Titolo:
Coordinate expression of membrane type-matrix metalloproteinases-2 and 3 (MT2-MMP and MT3-MMP) and matrix metalloproteinase-2 (MMP-2) in primary and metastatic melanoma cells
Autore:
Ohnishi, Y; Tajima, S; Ishibashi, A;
Indirizzi:
Natl Def Med Coll, Dept Dermatol, Tokorozawa, Saitama 3598513, Japan Natl Def Med Coll Tokorozawa Saitama Japan 3598513 Saitama 3598513, Japan
Titolo Testata:
EUROPEAN JOURNAL OF DERMATOLOGY
fascicolo: 5, volume: 11, anno: 2001,
pagine: 420 - 423
SICI:
1167-1122(200109/10)11:5<420:CEOMTM>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
IV COLLAGENASE; EXTRACELLULAR-MATRIX; TISSUE LOCALIZATION; PROGNOSTIC VALUE; CDNA LIBRARY; ACTIVATION; MT1-MMP; GENE; CARCINOMAS; IDENTIFICATION;
Keywords:
membrane type-matrix metalloproteinases-2; membrane type-matrix metalloproteinases-3; matrix metalloproteinase-2; malignant melanoma;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Tajima, S Natl Def Med Coll, Dept Dermatol, 3-2 Namiki, Tokorozawa, Saitama 3598513,Japan Natl Def Med Coll 3-2 Namiki Tokorozawa Saitama Japan 3598513 an
Citazione:
Y. Ohnishi et al., "Coordinate expression of membrane type-matrix metalloproteinases-2 and 3 (MT2-MMP and MT3-MMP) and matrix metalloproteinase-2 (MMP-2) in primary and metastatic melanoma cells", EUR J DERM, 11(5), 2001, pp. 420-423

Abstract

Expression of MMP-2 in melanoma cells has been demonstrated to be involvedin the degradation of extracellular matrix during melanoma growth and to correlate with later melanoma metastasis. MMP-2 is considered to be activated by membrane-associated matrix metalloproteinases (MT-MMPs). To know whether MT-MMPs are involved in the activation of MMP-2 in melanoma cells, immunohistochemical studies were performed in primary and metastatic melanoma byuse of the antibodies for MT1-MMP, MT2-MMP and MT3-MMP. Expression of MT1-MMP, MT2-MMP, MT3-MMP and MMP-2 in nevocellular nevus (n = 5), dysplastic nevus (n = 2) and juvenile melanoma (n = 3) was undetectable or detected in only a few cells. Superficial spreading melanoma (SSM) (n = 3) and acral lentiginous melanoma (ALM) (n = 3) showed a moderate expression of MT1 similar to3-MMP. In nodular melanoma (NM) (n = 2) and metastatic melanoma (n = 3), MT1 similar to3-MMP was more, intensely expressed. Double immunofluorescence demonstrated a consistent colocalization of MT2-MMP/MMP-2 and MT3-MMP/MMP-2 in the NM and metastatic melanoma cells. The colocalization of MT2,3-MMP and MMP-2 in nodular and metastatic melanoma cells suggests that MT-MMPsand MMP-2 co-operate in the invasive and metastatic process of melanoma cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 11:20:55